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dc.contributor.authorKim, Honesty
dc.contributor.authorJin, Xiaofan
dc.contributor.authorGlass, David S
dc.contributor.authorRiedel-Kruse, Ingmar H
dc.date.accessioned2020-10-05T22:35:37Z
dc.date.available2020-10-05T22:35:37Z
dc.date.issued2020-07-03
dc.identifier.citationKim, H., Jin, X., Glass, D. S., & Riedel-Kruse, I. H. (2020). Engineering and modeling of multicellular morphologies and patterns. Current opinion in genetics & development, 63, 95-102.en_US
dc.identifier.issn0959-437X
dc.identifier.pmid32629326
dc.identifier.doi10.1016/j.gde.2020.05.039
dc.identifier.urihttp://hdl.handle.net/10150/647628
dc.description.abstractSynthetic multicellular (MC) systems have the capacity to increase our understanding of biofilms and higher organisms, and to serve as engineering platforms for developing complex products in the areas of medicine, biosynthesis and smart materials. Here we provide an interdisciplinary perspective and review on emerging approaches to engineer and model MC systems. We lay out definitions for key terms in the field and identify toolboxes of standardized parts which can be combined into various MC algorithms to achieve specific outcomes. Many essential parts and algorithms have been demonstrated in some form. As key next milestones for the field, we foresee the improvement of these parts and their adaptation to more biological systems, the demonstration of more complex algorithms, the advancement of quantitative modeling approaches and compilers to support rational MC engineering, and implementation of MC engineering for practical applications.en_US
dc.language.isoenen_US
dc.publisherCURRENT BIOLOGY LTDen_US
dc.rightsCopyright © 2020 Elsevier Ltd. All rights reserved.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.titleEngineering and modeling of multicellular morphologies and patternsen_US
dc.typeArticleen_US
dc.identifier.eissn1879-0380
dc.contributor.departmentUniv Arizona, Dept Mol & Cellular Biolen_US
dc.identifier.journalCurrent opinion in genetics & developmenten_US
dc.description.note12 month embargo; available online 3 July 2020en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleCurrent opinion in genetics & development
dc.source.volume63
dc.source.beginpage95
dc.source.endpage102
dc.source.countryEngland


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