Inner structure- and surface-controlled hollow MnO nanocubes for high sensitive MR imaging contrast effect
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Author
Kukreja, AasthaKang, Byunghoon
Han, Seungmin
Shin, Moo-Kwang
Son, Hye Young
Choi, Yuna
Lim, Eun-Kyung
Huh, Yong-Min
Haam, Seungjoo
Affiliation
Univ Arizona, Dept SurgIssue Date
2020-05-12Keywords
Hollow nanostructureLigand encapsulation and exchange
Manganese oxide nanocube
MR imaging
T1 contrast agent
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Kukreja, A., Kang, B., Han, S., Shin, M. K., Son, H. Y., Choi, Y., ... & Haam, S. (2020). Inner structure-and surface-controlled hollow MnO nanocubes for high sensitive MR imaging contrast effect. Nano Convergence, 7, 1-11.Journal
NANO CONVERGENCERights
Copyright © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Manganese oxide (MnO) nanocubes were fabricated and their surface were modified by ligand encapsulation or ligand exchange, to render them water-soluble. And then, MnO formed the hollow structure by etching using acidic solution (phthalate buffer, pH 4.0). Depending on the ligand of the MnO surface, it increases the interaction between MnO and water molecules. Also, the hollow structure of MnO, as well as the ligand, can greatly enhance the accessibility of water molecules to metal ions by surface area-to-volume ratio. These factors provide high R1 relaxation, leading to strong T1 MRI signal. We have confirmed T1-weighted MR contrast effect using 4-kinds of MnO nanocubes (MnOEn, MnOEnHo, MnOEx and MnOExHo). They showed enough a MR contrast effect and biocompatibility. Especially, among them, MnOExHo exhibited high T1 relaxivity (r1) (6.02 mM-1 s-1), even about 1.5 times higher sensitivity than commercial T1 MR contrast agents. In vitro/in vivo studies have shown that MnOExHo provides highly sensitive T1-weighted MR imaging, thereby improving diagnostic visibility at the disease site.Note
Open access journalISSN
2196-5404PubMed ID
32394133Version
Final published versionae974a485f413a2113503eed53cd6c53
10.1186/s40580-020-00227-6
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Except where otherwise noted, this item's license is described as Copyright © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License.