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dc.contributor.authorBernardi, Alyssa M
dc.contributor.authorMoses, Sylvestor
dc.contributor.authorBarber, Brent J
dc.contributor.authorWitte, Marlys H
dc.contributor.authorSeckeler, Michael D
dc.date.accessioned2020-11-03T00:38:54Z
dc.date.available2020-11-03T00:38:54Z
dc.date.issued2020-09-25
dc.identifier.citationBernardi, A.M., Moses, S., Barber, B.J. et al. Higher Incidence of Protein-Losing Enteropathy in Patients with Single Systemic Right Ventricle. Pediatr Cardiol (2020). https://doi.org/10.1007/s00246-020-02468-yen_US
dc.identifier.issn0172-0643
dc.identifier.pmid32975605
dc.identifier.doi10.1007/s00246-020-02468-y
dc.identifier.urihttp://hdl.handle.net/10150/648090
dc.description.abstractPatients with single ventricle congenital heart disease are at risk of unpredictable protein-losing enteropathy (PLE) after surgical palliation. Based on prior reports of physiologic differences for patients with single morphologic right versus left ventricles, we hypothesized that those with right ventricular morphology would have a higher incidence of PLE. We performed a retrospective review of > 15 million pediatric hospitalizations from the Healthcare Cost and Utilization Project KID 2000-2012 databases for admissions 5-21 years old with ICD-9 codes for hypoplastic left heart syndrome (HLHS) and tricuspid atresia (TA) with and without PLE. Incidence of PLE was compared between those with HLHS and TA. In addition, outcomes and costs were compared between admissions with and without PLE and between HLHS and TA. Of 1623 HLHS admissions, 289 (17.8%) had PLE, and of 926 TA admissions, 58 (5.9%) had PLE (p < 0.001). Admissions with PLE were older compared to those without PLE (12 vs 10 years, p < 0.001) and PLE onset occurred at a younger age for HLHS than TA (11 vs 14 years, p < 0.001). There were no differences in hospital outcomes or costs. Review of this large administrative database suggests a higher incidence of PLE in patients with HLHS and a younger age of onset compared to those with TA. These data suggest that a single systemic right ventricle may be an independent risk factor for developing PLE.en_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.rightsCopyright © Springer Science + Business Media, LLC, part of Springer Nature 2020.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.subjectCongenital heart defectsen_US
dc.subjectFontanen_US
dc.subjectProtein-losing enteropathyen_US
dc.subjectSingle ventricleen_US
dc.titleHigher Incidence of Protein-Losing Enteropathy in Patients with Single Systemic Right Ventricleen_US
dc.typeArticleen_US
dc.identifier.eissn1432-1971
dc.contributor.departmentUniv Arizona, Dept Pediaten_US
dc.contributor.departmentUniv Arizona, Dept Internal Meden_US
dc.contributor.departmentUniv Arizona, Dept Pediat Cardiolen_US
dc.contributor.departmentUniv Arizona, Dept Surgen_US
dc.identifier.journalPEDIATRIC CARDIOLOGYen_US
dc.description.note12 month embargo; published 25 September 2020en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitlePediatric cardiology
dc.source.countryUnited States


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