Understanding allergic multimorbidity within the non-eosinophilic interactome
Koppelman, Gerard H
Anto, Josep M
AffiliationAsthma & Airway Dis Res Ctr
MetadataShow full item record
PublisherPUBLIC LIBRARY SCIENCE
CitationAguilar, D., Lemonnier, N., Koppelman, G. H., Melén, E., Oliva, B., Pinart, M., ... & Anto, J. M. (2019). Understanding allergic multimorbidity within the non-eosinophilic interactome. PloS one, 14(11), e0224448.
Rights© 2019 Aguilar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
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AbstractBackground The mechanisms explaining multimorbidity between asthma, dermatitis and rhinitis (allergic multimorbidity) are not well known. We investigated these mechanisms and their specificity in distinct cell types by means of an interactome-based analysis of expression data. Methods Genes associated to the diseases were identified using data mining approaches, and their multimorbidity mechanisms in distinct cell types were characterized by means of an in silico analysis of the topology of the human interactome. Results We characterized specific pathomechanisms for multimorbidities between asthma, dermatitis and rhinitis for distinct emergent non-eosinophilic cell types. We observed differential roles for cytokine signaling, TLR-mediated signaling and metabolic pathways for multimorbidities across distinct cell types. Furthermore, we also identified individual genes potentially associated to multimorbidity mechanisms. Conclusions Our results support the existence of differentiated multimorbidity mechanisms between asthma, dermatitis and rhinitis at cell type level, as well as mechanisms common to distinct cell types. These results will help understanding the biology underlying allergic multimorbidity, assisting in the design of new clinical studies.
NoteOpen access journal
VersionFinal published version
Except where otherwise noted, this item's license is described as © 2019 Aguilar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
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