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dc.contributor.authorAguilar, Daniel
dc.contributor.authorLemonnier, Nathanael
dc.contributor.authorKoppelman, Gerard H
dc.contributor.authorMelén, Erik
dc.contributor.authorOliva, Baldo
dc.contributor.authorPinart, Mariona
dc.contributor.authorGuerra, Stefano
dc.contributor.authorBousquet, Jean
dc.contributor.authorAnto, Josep M
dc.date.accessioned2020-11-14T01:20:17Z
dc.date.available2020-11-14T01:20:17Z
dc.date.issued2019-11-06
dc.identifier.citationAguilar, D., Lemonnier, N., Koppelman, G. H., Melén, E., Oliva, B., Pinart, M., ... & Anto, J. M. (2019). Understanding allergic multimorbidity within the non-eosinophilic interactome. PloS one, 14(11), e0224448.en_US
dc.identifier.issn1932-6203
dc.identifier.pmid31693680
dc.identifier.doi10.1371/journal.pone.0224448
dc.identifier.urihttp://hdl.handle.net/10150/648520
dc.description.abstractBackground The mechanisms explaining multimorbidity between asthma, dermatitis and rhinitis (allergic multimorbidity) are not well known. We investigated these mechanisms and their specificity in distinct cell types by means of an interactome-based analysis of expression data. Methods Genes associated to the diseases were identified using data mining approaches, and their multimorbidity mechanisms in distinct cell types were characterized by means of an in silico analysis of the topology of the human interactome. Results We characterized specific pathomechanisms for multimorbidities between asthma, dermatitis and rhinitis for distinct emergent non-eosinophilic cell types. We observed differential roles for cytokine signaling, TLR-mediated signaling and metabolic pathways for multimorbidities across distinct cell types. Furthermore, we also identified individual genes potentially associated to multimorbidity mechanisms. Conclusions Our results support the existence of differentiated multimorbidity mechanisms between asthma, dermatitis and rhinitis at cell type level, as well as mechanisms common to distinct cell types. These results will help understanding the biology underlying allergic multimorbidity, assisting in the design of new clinical studies.en_US
dc.language.isoenen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.rights© 2019 Aguilar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleUnderstanding allergic multimorbidity within the non-eosinophilic interactomeen_US
dc.typeArticleen_US
dc.contributor.departmentAsthma & Airway Dis Res Ctren_US
dc.identifier.journalPLOS ONEen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitlePloS one
dc.source.volume14
dc.source.issue11
dc.source.beginpagee0224448
dc.source.endpage
refterms.dateFOA2020-11-14T01:20:31Z
dc.source.countryUnited States


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© 2019 Aguilar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
Except where otherwise noted, this item's license is described as © 2019 Aguilar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.