Development of an integrated fingerstick blood self-collection device for radiation countermeasures
Brenner, David J
AffiliationUniv Arizona, Coll Med, Ctr Appl NanoBiosci & Med
MetadataShow full item record
PublisherPUBLIC LIBRARY SCIENCE
CitationGu, J., Norquist, A., Brooks, C., Repin, M., Mukherjee, S., Lacombe, J., ... & Zenhausern, F. (2019). Development of an integrated fingerstick blood self-collection device for radiation countermeasures. PloS one, 14(10), e0222951.
Rights© 2019 Gu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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AbstractWe report the development of system for packaging critical components of the traditional collection kit to make an integrated fingerstick blood collector for self-collecting blood samples of 100 mu l or more for radiation countermeasures. A miniaturized vacuum tube system (VacuStor system) has been developed to facilitate liquid reagent storage, simple operation and reduced sample contamination. Vacuum shelf life of the VacuStor tube has been analyzed by the ideal gas law and gas permeation theory, and multiple ways to extend vacuum shelf life beyond one year have been demonstrated, including low temperature storage, Parylene barrier coating and container vacuum bag sealing. Self-collection was also demonstrated by healthy donors without any previous fingerstick collection experience. The collected blood samples showed similar behavior in terms of gene expression and cytogenetic biodosimetry assays comparing to the traditionally collected samples. The integrated collector may alleviate the sample collection bottleneck for radiation countermeasures following a large-scale nuclear event, and may be useful in other applications with its self-collection and liquid reagent sample preprocessing capabilities.
NoteOpen access journal
VersionFinal published version
Except where otherwise noted, this item's license is described as © 2019 Gu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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