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    Survival following allogeneic transplant in patients with myelofibrosis

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    Author
    Gowin, Krisstina
    Ballen, Karen
    Ahn, Kwang Woo
    Hu, Zhen-Huan
    Ali, Haris
    Arcasoy, Murat O
    Devlin, Rebecca
    Coakley, Maria
    Gerds, Aaron T
    Green, Michael
    Gupta, Vikas
    Hobbs, Gabriela
    Jain, Tania
    Kandarpa, Malathi
    Komrokji, Rami
    Kuykendall, Andrew T
    Luber, Kierstin
    Masarova, Lucia
    Michaelis, Laura C
    Patches, Sarah
    Pariser, Ashley C
    Rampal, Raajit
    Stein, Brady
    Talpaz, Moshe
    Verstovsek, Srdan
    Wadleigh, Martha
    Agrawal, Vaibhav
    Aljurf, Mahmoud
    Angel Diaz, Miguel
    Avalos, Belinda R
    Bacher, Ulrike
    Bashey, Asad
    Beitinjaneh, Amer M
    Cerny, Jan
    Chhabra, Saurabh
    Copelan, Edward
    Cutler, Corey S
    DeFilipp, Zachariah
    Gadalla, Shahinaz M
    Ganguly, Siddhartha
    Grunwald, Michael R
    Hashmi, Shahrukh K
    Kharfan-Dabaja, Mohamed A
    Kindwall-Keller, Tamila
    Kröger, Nicolaus
    Lazarus, Hillard M
    Liesveld, Jane L
    Litzow, Mark R
    Marks, David I
    Nathan, Sunita
    Nishihori, Taiga
    Olsson, Richard F
    Pawarode, Attaphol
    Rowe, Jacob M
    Savani, Bipin N
    Savoie, Mary Lynn
    Seo, Sachiko
    Solh, Melhem
    Tamari, Roni
    Verdonck, Leo F
    Yared, Jean A
    Alyea, Edwin
    Popat, Uday
    Sobecks, Ronald
    Scott, Bart L
    Nakamura, Ryotaro
    Mesa, Ruben
    Saber, Wael
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    Affiliation
    Univ Arizona, Div Hematol & Oncol
    Issue Date
    2020-05-08
    
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    Publisher
    AMER SOC HEMATOLOGY
    Citation
    Gowin, K., Ballen, K., Ahn, K. W., Hu, Z. H., Ali, H., Arcasoy, M. O., ... & Saber, W. (2020). Survival following allogeneic transplant in patients with myelofibrosis. Blood advances, 4(9), 1965-1973.
    Journal
    BLOOD ADVANCES
    Rights
    © 2020 by The American Society of Hematology.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Allogeneic hematopoietic cell transplantation (HCT) is the only curative therapy for myelofibrosis (MF). In this large multicenter retrospective study, overall survival (OS) in MF patients treated with allogeneic HCT (551 patients) and without HCT (non-HCT) (1377 patients) was analyzed with Cox proportional hazards model. Survival analysis stratified by the Dynamic International Prognostic Scoring System (DIPSS) revealed that the first year of treatment arm assignment, due to upfront risk of transplant-related mortality (TRM), HCT was associated with inferior OS compared with non-HCT (non-HCT vs HCT: DIPSS intermediate 1 [Int-1]: hazard ratio [HR] = 0.26, P < .0001; DIPSS-Int-2 and higher: HR, 0.39, P < .0001). Similarly, in the DIPSS low-risk MF group, due to upfront TRM risk, OS was superior with non-HCT therapies compared with HCT in the first-year post treatment arm assignment (HR, 0.16, P = .006). However, after 1 year, OS was not significantly different (HR, 1.38, P = .451). Beyond 1 year of treatment arm assignment, an OS advantage with HCT therapy in Int-1 and higher DIPSS score patients was observed (non-HCT vs HCT: DIPSS-Int-1: HR, 2.64, P < .0001; DIPSS-Int-2 and higher: HR, 2.55, P < .0001). In conclusion, long-term OS advantage with HCT was observed for patients with Int-1 or higher risk MF, but at the cost of early TRM. The magnitude of OS benefit with HCT increased as DIPSS risk score increased and became apparent with longer follow-up.
    ISSN
    2473-9529
    EISSN
    2473-9537
    PubMed ID
    32384540
    DOI
    10.1182/bloodadvances.2019001084
    Version
    Final published version
    ae974a485f413a2113503eed53cd6c53
    10.1182/bloodadvances.2019001084
    Scopus Count
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    UA Faculty Publications

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