Neural Circuit Mechanism Underlying the Feeding Controlled by Insula-Central Amygdala Pathway
AffiliationUniv Arizona, Dept Math
Univ Arizona, Dept Neurosci
Univ Arizona, Grad Interdisciplinary Program Neurosci
Univ Arizona, Bio5 Inst
Univ Arizona, Dept Neurol
MetadataShow full item record
CitationZhang-Molina, C., Schmit, M. B., & Cai, H. (2020). Neural circuit mechanism underlying the feeding controlled by insula-central amygdala pathway. Iscience, 101033.
RightsCopyright © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractThe Central nucleus of amygdala (CeA) contains distinct populations of neurons that play opposing roles in feeding. The circuit mechanism of how CeA neurons process information sent fromtheir upstreaminputs to regulate feeding is still unclear. Here we show that activation of the neural pathway projecting from insular cortex neurons to the CeA suppresses food intake. Surprisingly, we find that the inputs from insular cortex form excitatory connections with similar strength to all types of CeA neurons. To reconcile this puzzling result, and previous findings, we developed a conductance-based dynamical systems model for the CeA neuronal network. Computer simulations showed that both the intrinsic electrophysiological properties of individual CeA neurons and the overall synaptic organization of the CeA circuit play a functionally significant role in shaping CeA neural dynamics. We successfully identified a specific CeA circuit structure that reproduces the desired circuit output consistent with existing experimentally observed feeding behaviors.
NoteOpen access journal
VersionFinal published version
Except where otherwise noted, this item's license is described as Copyright © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- The Insula Cortex Contacts Distinct Output Streams of the Central Amygdala.
- Authors: Ponserre M, Peters C, Fermani F, Conzelmann KK, Klein R
- Issue date: 2020 Nov 11
- An Insula-Central Amygdala Circuit for Guiding Tastant-Reinforced Choice Behavior.
- Authors: Schiff HC, Bouhuis AL, Yu K, Penzo MA, Li H, He M, Li B
- Issue date: 2018 Feb 7
- Dissecting a disynaptic central amygdala-parasubthalamic nucleus neural circuit that mediates cholecystokinin-induced eating suppression.
- Authors: Sanchez MR, Wang Y, Cho TS, Schnapp WI, Schmit MB, Fang C, Cai H
- Issue date: 2022 Apr
- The loop neural circuit between the medial prefrontal cortex and the amygdala in the rat brain.
- Authors: Ishikawa J, Ishikawa A
- Issue date: 2019 Nov 1
- The central amygdala to periaqueductal gray pathway comprises intrinsically distinct neurons differentially affected in a model of inflammatory pain.
- Authors: Li JN, Sheets PL
- Issue date: 2018 Dec