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    Targeting the renin-angiotensin-aldosterone system in fibrosis

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    Author
    AlQudah, Mohammad
    Hale, Taben M
    Czubryt, Michael P
    Affiliation
    Univ Arizona, Dept Basic Med Sci, Coll Med Phoenix
    Issue Date
    2020-05-16
    Keywords
    Angiotensin II
    Extracellular matrix
    fibroblast
    Myofibroblast
    Therapeutics
    Wound healing
    
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    ELSEVIER
    Citation
    AlQudah, M., Hale, T. M., & Czubryt, M. P. (2020). Targeting the renin-angiotensin-aldosterone system in fibrosis. Matrix Biology, 91, 92-108.
    Journal
    MATRIX BIOLOGY
    Rights
    Copyright © 2020 Elsevier B.V. All rights reserved.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Fibrosis is characterized by excessive deposition of extracellular matrix components such as collagen in tis-sues or organs. Fibrosis can develop in the heart, kidneys, liver, skin or any other body organ in response to injury or maladaptive reparative processes, reducing overall function and leading eventually to organ failure. A variety of cellular and molecular signaling mechanisms are involved in the pathogenesis of fibrosis. The renin-angiotensin-aldosterone system (RAAS) interacts with the potent Transforming Growth Factor beta (TGF beta) pro-fibrotic pathway to mediate fibrosis in many cell and tissue types. RAAS consists of both classical and alternative pathways, which act to potentiate or antagonize fibrotic signaling mechanisms, respectively. This review provides an overview of recent literature describing the roles of RAAS in the pathogenesis of fibrosis, particularly in the liver, heart, kidney and skin, and with a focus on RAAS interactions with TGF beta sig-naling. Targeting RAAS to combat fibrosis represents a promising therapeutic approach, particularly given the lack of strategies for treating fibrosis as its own entity, thus animal and clinical studies to examine the impact of natural and synthetic substances to alter RAAS signaling as a means to treat fibrosis are reviewed as well. (c) 2020 Elsevier B.V. All rights reserved.
    Note
    12 month embargo; published online 16 May 2020
    ISSN
    0945-053X
    EISSN
    1569-1802
    PubMed ID
    32422329
    DOI
    10.1016/j.matbio.2020.04.005
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.matbio.2020.04.005
    Scopus Count
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