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    Brain site-specific regulation of hedonic intake by orexin and DYN peptides: role of the PVN and obesity

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    Name:
    Mattar et al. 2020.pdf
    Embargo:
    2021-11-05
    Size:
    2.929Mb
    Format:
    PDF
    Description:
    Final Accepted Manuscript
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    Author
    Mattar, P
    Uribe-Cerda, S
    Pezoa, C
    Guarnieri, T
    Kotz, C M
    Teske, J A
    Morselli, E
    Perez-Leighton, C
    Affiliation
    Univ Arizona, Dept Nutr Sci
    Issue Date
    2020-11-05
    Keywords
    orexin
    hypocretin
    dynorphin
    cafeteria diet
    hypothalamus
    obesity
    hedonic intake
    food choice
    feeding behavior
    fat
    orexin 1 receptor
    opioid receptors
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    Publisher
    TAYLOR & FRANCIS LTD
    Citation
    Mattar, P., Uribe-Cerda, S., Pezoa, C., Guarnieri, T., Kotz, C. M., Teske, J. A., ... & Perez-Leighton, C. (2020). Brain site-specific regulation of hedonic intake by orexin and DYN peptides: role of the PVN and obesity. Nutritional Neuroscience, 1-10.
    Journal
    NUTRITIONAL NEUROSCIENCE
    Rights
    © 2020 Informa UK Limited, trading as Taylor & Francis Group
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The orexin peptides promote hedonic intake and other reward behaviors through different brain sites. The opioid dynorphin peptides are co-released with orexin peptides but block their effects on reward in the ventral tegmental area (VTA). We previously showed that in the paraventricular hypothalamic nucleus (PVN), dynorphin and not orexin peptides enhance hedonic intake, suggesting they have brain-site-specific effects. Obesity alters the expression of orexin and dynorphin receptors, but whether their expression across different brain sites is important to hedonic intake is unclear. We hypothesized that hedonic intake is regulated by orexin and dynorphin peptides in PVN and that hedonic intake in obesity correlates with expression of their receptors. Here we show that in mice, injection of DYN-A1-13 (an opioid dynorphin peptide) in the PVN enhanced hedonic intake, whereas in the VTA, injection of OXA (orexin-A, an orexin peptide) enhanced hedonic intake. In PVN, OXA blunted the increase in hedonic intake caused by DYN-A1-13. In PVN, injection of norBNI (opioid receptor antagonist) reduced hedonic intake but a subsequent OXA injection failed to increase hedonic intake, suggesting that OXA activity in PVN is not influenced by endogenous opioid activity. In the PVN, DYN-A1-13 increased the intake of the less-preferred food in a two-food choice task. In obese mice fed a cafeteria diet, orexin 1 receptor mRNA across brain sites involved in hedonic intake correlated with fat preference but not caloric intake. Together, these data support that orexin and dynorphin peptides regulate hedonic intake in an opposing manner with brain-site-specific effects.
    Note
    12 month embargo; published 5 November 2020
    ISSN
    1028-415X
    EISSN
    1476-8305
    PubMed ID
    33151127
    DOI
    10.1080/1028415X.2020.1840049
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1080/1028415X.2020.1840049
    Scopus Count
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    UA Faculty Publications

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