Brain site-specific regulation of hedonic intake by orexin and DYN peptides: role of the PVN and obesity
Name:
Mattar et al. 2020.pdf
Embargo:
2021-11-05
Size:
2.929Mb
Format:
PDF
Description:
Final Accepted Manuscript
Affiliation
Univ Arizona, Dept Nutr SciIssue Date
2020-11-05Keywords
orexinhypocretin
dynorphin
cafeteria diet
hypothalamus
obesity
hedonic intake
food choice
feeding behavior
fat
orexin 1 receptor
opioid receptors
Metadata
Show full item recordPublisher
TAYLOR & FRANCIS LTDCitation
Mattar, P., Uribe-Cerda, S., Pezoa, C., Guarnieri, T., Kotz, C. M., Teske, J. A., ... & Perez-Leighton, C. (2020). Brain site-specific regulation of hedonic intake by orexin and DYN peptides: role of the PVN and obesity. Nutritional Neuroscience, 1-10.Journal
NUTRITIONAL NEUROSCIENCERights
© 2020 Informa UK Limited, trading as Taylor & Francis GroupCollection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
The orexin peptides promote hedonic intake and other reward behaviors through different brain sites. The opioid dynorphin peptides are co-released with orexin peptides but block their effects on reward in the ventral tegmental area (VTA). We previously showed that in the paraventricular hypothalamic nucleus (PVN), dynorphin and not orexin peptides enhance hedonic intake, suggesting they have brain-site-specific effects. Obesity alters the expression of orexin and dynorphin receptors, but whether their expression across different brain sites is important to hedonic intake is unclear. We hypothesized that hedonic intake is regulated by orexin and dynorphin peptides in PVN and that hedonic intake in obesity correlates with expression of their receptors. Here we show that in mice, injection of DYN-A1-13 (an opioid dynorphin peptide) in the PVN enhanced hedonic intake, whereas in the VTA, injection of OXA (orexin-A, an orexin peptide) enhanced hedonic intake. In PVN, OXA blunted the increase in hedonic intake caused by DYN-A1-13. In PVN, injection of norBNI (opioid receptor antagonist) reduced hedonic intake but a subsequent OXA injection failed to increase hedonic intake, suggesting that OXA activity in PVN is not influenced by endogenous opioid activity. In the PVN, DYN-A1-13 increased the intake of the less-preferred food in a two-food choice task. In obese mice fed a cafeteria diet, orexin 1 receptor mRNA across brain sites involved in hedonic intake correlated with fat preference but not caloric intake. Together, these data support that orexin and dynorphin peptides regulate hedonic intake in an opposing manner with brain-site-specific effects.Note
12 month embargo; published 5 November 2020ISSN
1028-415XEISSN
1476-8305PubMed ID
33151127Version
Final accepted manuscriptae974a485f413a2113503eed53cd6c53
10.1080/1028415X.2020.1840049
Scopus Count
Collections
Related articles
- Role of the non-opioid dynorphin peptide des-Tyr-dynorphin (DYN-A(2-17)) in food intake and physical activity, and its interaction with orexin-A.
- Authors: Gac L, Butterick TA, Duffy CM, Teske JA, Perez-Leighton CE
- Issue date: 2016 Feb
- Effects on Hedonic Feeding, Energy Expenditure and Balance of the Non-opioid Peptide DYN-A<sub>2-17</sub>.
- Authors: Alvarez B, Barrientos T, Gac L, Teske JA, Perez-Leighton CE
- Issue date: 2018 Feb 10
- Effect of ethanol on hypothalamic opioid peptides, enkephalin, and dynorphin: relationship with circulating triglycerides.
- Authors: Chang GQ, Karatayev O, Ahsan R, Avena NM, Lee C, Lewis MJ, Hoebel BG, Leibowitz SF
- Issue date: 2007 Feb
- Dietary fat stimulates endogenous enkephalin and dynorphin in the paraventricular nucleus: role of circulating triglycerides.
- Authors: Chang GQ, Karatayev O, Ahsan R, Gaysinskaya V, Marwil Z, Leibowitz SF
- Issue date: 2007 Feb
- Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area.
- Authors: Muschamp JW, Hollander JA, Thompson JL, Voren G, Hassinger LC, Onvani S, Kamenecka TM, Borgland SL, Kenny PJ, Carlezon WA Jr
- Issue date: 2014 Apr 22