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dc.contributor.authorCrown, Lindsey M
dc.contributor.authorBartlett, Mitchell J
dc.contributor.authorWiegand, Jean-Paul L
dc.contributor.authorEby, Allison J
dc.contributor.authorMonroe, Emily J
dc.contributor.authorGies, Kathleen
dc.contributor.authorWohlford, Luke
dc.contributor.authorFell, Matthew J
dc.contributor.authorFalk, Torsten
dc.contributor.authorCowen, Stephen L
dc.date.accessioned2020-12-05T03:24:24Z
dc.date.available2020-12-05T03:24:24Z
dc.date.issued2020-05-08
dc.identifier.citationCrown, L. M., Bartlett, M. J., Wiegand, J. P. L., Eby, A. J., Monroe, E. J., Gies, K., ... & Cowen, S. L. (2020). Sleep Spindles and Fragmented Sleep as Prodromal Markers in a Preclinical Model of LRRK2-G2019S Parkinson's Disease. Frontiers in Neurology, 11, 324.en_US
dc.identifier.issn1664-2295
dc.identifier.pmid32477237
dc.identifier.doi10.3389/fneur.2020.00324
dc.identifier.urihttp://hdl.handle.net/10150/649236
dc.description.abstractSleep disturbances co-occur with and precede the onset of motor symptoms in Parkinson's disease (PD). We evaluated sleep fragmentation and thalamocortical sleep spindles in mice expressing the p.G2019S mutation of the leucine-rich repeat kinase 2 (LRRK2) gene, one of the most common genetic forms of PD. Thalamocortical sleep spindles are oscillatory events that occur during slow-wave sleep that are involved in memory consolidation. We acquired data from electrocorticography, sleep behavioral measures, and a rotarod-based motor enrichment task in 28 LRRK2-G2019S knock-in mice and 27 wild-type controls (8-10 month-old males). Sleep was more fragmented in LRRK2-G2019S mice; sleep bouts were shorter and more numerous, even though total sleep time was similar to controls. LRRK2-G2019S animals expressed more sleep spindles, and individual spindles were longer in duration than in controls. We then chronically administered the LRRK2-inhibitor MLi-2 in-diet to n = 12 LRRK2-G2019S and n = 15 wild-type mice for a within-subject analysis of the effects of kinase inhibition on sleep behavior and physiology. Treatment with MLi-2 did not impact these measures. The data indicate that the LRRK2-G2019S mutation could lead to reduced sleep quality and altered sleep spindle physiology. This suggests that sleep spindles in LRRK2-G2019S animals could serve as biomarkers for underlying alterations in sleep networks resulting from the LRRK2-G2019S mutation, and further evaluation in human LRRK2-G2019S carriers is therefore warranted.en_US
dc.language.isoenen_US
dc.publisherFRONTIERS MEDIA SAen_US
dc.rightsCopyright © 2020 Crown, Bartlett, Wiegand, Eby, Monroe, Gies, Wohlford, Fell, Falk and Cowen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectParkinson's diseaseen_US
dc.subjectprodromalen_US
dc.subjectLRRK2en_US
dc.subjectsleep spindlesen_US
dc.subjectsleep fragmentationen_US
dc.subjectEEGen_US
dc.subjectbiomarkeren_US
dc.titleSleep Spindles and Fragmented Sleep as Prodromal Markers in a Preclinical Model of LRRK2-G2019S Parkinson's Diseaseen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Psycholen_US
dc.contributor.departmentUniv Arizona, Dept Neurolen_US
dc.contributor.departmentUniv Arizona, Dept Pharmacolen_US
dc.contributor.departmentUniv Arizona, Grad Interdisciplinary Program Neuroscien_US
dc.contributor.departmentUniv Arizona, Dept Physiolen_US
dc.contributor.departmentUniv Arizona, Dept Biomed Engnen_US
dc.contributor.departmentUniv Arizona, Coll Meden_US
dc.identifier.journalFRONTIERS IN NEUROLOGYen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleFrontiers in neurology
dc.source.volume11
dc.source.beginpage324
dc.source.endpage
refterms.dateFOA2020-12-05T03:24:40Z
dc.source.countrySwitzerland


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Copyright © 2020 Crown, Bartlett, Wiegand, Eby, Monroe, Gies, Wohlford, Fell, Falk and Cowen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Except where otherwise noted, this item's license is described as Copyright © 2020 Crown, Bartlett, Wiegand, Eby, Monroe, Gies, Wohlford, Fell, Falk and Cowen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).