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dc.contributor.authorMorgan, Michael M
dc.contributor.authorPeecher, Danielle L
dc.contributor.authorStreicher, John M
dc.date.accessioned2020-12-15T18:24:53Z
dc.date.available2020-12-15T18:24:53Z
dc.date.issued2020-10-06
dc.identifier.citationMorgan, M. M., Peecher, D. L., & Streicher, J. M. (2020). Use of home cage wheel running to assess the behavioural effects of administering a mu/delta opioid receptor heterodimer antagonist for spontaneous morphine withdrawal in the rat. Behavioural Brain Research, 397, 112953.en_US
dc.identifier.issn0166-4328
dc.identifier.pmid33031872
dc.identifier.doi10.1016/j.bbr.2020.112953
dc.identifier.urihttp://hdl.handle.net/10150/649275
dc.description.abstractOpioid abuse is a major health problem. The objective of the present study was to evaluate the potentially disruptive side effects and therapeutic potential of a novel antagonist (D24M) of the mu-/delta-opioid receptor (MOR/DOR) heterodimer in male rats. Administration of high doses of D24M (1 & 10 nmol) into the lateral ventricle did not disrupt home cage wheel running. Repeated twice daily administration of increasing doses of morphine (5-20 mg/kg) over 5 days depressed wheel running and induced antinociceptive tolerance measured with the hot plate test. Administration of D24M had no effect on morphine tolerance, but tended to prolong morphine antinociception in non-tolerant rats. Spontaneous morphine withdrawal was evident as a decrease in body weight, a reduction in wheel running and an increase in sleep during the normally active dark phase of the circadian cycle, and an increase in wheel running and wakefulness in the normally inactive light phase. Administration of D24M during the dark phase on the third day of withdrawal had no effect on wheel running. These data provide additional evidence for the clinical relevance of home cage wheel running as a method to assess spontaneous opioid withdrawal in rats. These data also demonstrate that blocking the MOR/DOR heterodimer does not produce disruptive side effects or block the antinociceptive effects of morphine. Although administration of D24M had no effect on morphine withdrawal, additional studies are needed to evaluate withdrawal to continuous morphine administration and other opioids in rats with persistent pain.en_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.rightsCopyright © 2020 Elsevier B.V. All rights reserved.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.subjectMOR/DOR heterodimeren_US
dc.subjectAntinociceptionen_US
dc.subjectMorphine toleranceen_US
dc.subjectOpioid withdrawalen_US
dc.subjectWheel runningen_US
dc.titleUse of home cage wheel running to assess the behavioural effects of administering a mu/delta opioid receptor heterodimer antagonist for spontaneous morphine withdrawal in the raten_US
dc.typeArticleen_US
dc.identifier.eissn1872-7549
dc.contributor.departmentUniv Arizona, Coll Med, Dept Pharmacolen_US
dc.identifier.journalBEHAVIOURAL BRAIN RESEARCHen_US
dc.description.note18 month embargo; published online 6 October 2020en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleBehavioural brain research
dc.source.volume397
dc.source.beginpage112953
dc.source.endpage
dc.source.countryUnited States
dc.source.countryNetherlands


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