Single nucleotide polymorphisms of ADIPOQ gene associated with cardiovascular disease risk factors in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence study
AuthorSalazar-Tortosa, Diego F
Pascual-Gamarra, Jose M
Rupérez, Azahara I
Moreno, Luis A
Castillo, Manuel J
Ruiz, Jonatan R
AffiliationUniv Arizona, Dept Ecol & Evolutionary Biol
single nucleotide polymorphism
MetadataShow full item record
PublisherLIPPINCOTT WILLIAMS & WILKINS
CitationSalazar-Tortosa, D. F., Pascual-Gamarra, J. M., Labayen, I., Rupérez, A. I., Censi, L., Béghin, L., ... & Ruiz, J. R. (2020). Single nucleotide polymorphisms of ADIPOQ gene associated with cardiovascular disease risk factors in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence study. Journal of hypertension, 38(10), 1971-1979.
JournalJOURNAL OF HYPERTENSION
RightsCopyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractObjectives: Cardiovascular diseases (CVDs) are responsible of 31% of all deaths worldwide. Genetic predisposition to CVDs in adolescents remains largely unknown. Aims of present research are to examine the association of ADIPOQ gene polymorphisms with cardiovascular disease risk factors in European adolescents. Methods: A total of 14 polymorphisms in the ADIPOQ gene were genotyped in 1057 European adolescents (12-18 years old) from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study. We measured serum lipids and a CVD risk score, along with weight, height, triceps, and subscapular skinfold thickness, leptin, insulin and other markers of glucose regulation. Results: The rs822393, rs822395 and rs7649121 polymorphisms of ADIPOQ gene were significantly associated with several CVD risk factors [i.e. high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) A1, SBP and CVD risk score] in European adolescents. We also found an association of the TGAAGT ADIPOQ haplotype (rs822393, rs16861210, rs822395, rs822396, rs12495941 and rs7649121) with HDL-C and ApoA1 levels. Conclusion: Several individual polymorphisms (rs822393, rs822395 and rs7649121) and a haplotype of ADIPOQ gene were significantly associated with cardiovascular disease risk factors in European adolescents.
Note12 month embargo; published 01 October 2020
VersionFinal accepted manuscript
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