The Role of Resting-State Network Functional Connectivity in Cognitive Aging
AuthorHausman, Hanna K
Kraft, Jessica N
Boutzoukas, Emanuel M
Evangelista, Nicole D
Van Etten, Emily J
Bharadwaj, Pradyumna K
Smith, Samantha G
Hishaw, Georg A
Alexander, Gene E
Woods, Adam J
AffiliationUniv Arizona, Dept Psychol, McKnight Brain Inst
Univ Arizona, Coll Med, Dept Psychiat & Neurol
Univ Arizona, Dept Psychiat, Neurosci Grad Interdisciplinary Program
Univ Arizona, Dept Psychiat, Physiol Sci Grad Interdisciplinary Program
Univ Arizona, BIO5 Inst
MetadataShow full item record
PublisherFRONTIERS MEDIA SA
CitationHausman HK, O’Shea A, Kraft JN, Boutzoukas EM, Evangelista ND, Van Etten EJ, Bharadwaj PK, Smith SG, Porges E, Hishaw GA, Wu S, DeKosky S, Alexander GE, Marsiske M, Cohen R and Woods AJ (2020) The Role of Resting-State Network Functional Connectivity in Cognitive Aging. Front. Aging Neurosci. 12:177. doi: 10.3389/fnagi.2020.00177
JournalFRONTIERS IN AGING NEUROSCIENCE
RightsCopyright © 2020 Hausman, O’Shea, Kraft, Boutzoukas, Evangelista, Van Etten, Bharadwaj, Smith, Porges, Hishaw, Wu, DeKosky, Alexander, Marsiske, Cohen and Woods. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s)are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractAging is associated with disruptions in the resting-state functional architecture of the brain. Previous studies have primarily focused on age-related declines in the default mode network (DMN) and its implications in Alzheimer's disease. However, due to mixed findings, it is unclear if changes in resting-state network functional connectivity are linked to cognitive decline in healthy older adults. In the present study, we evaluated the influence of intra-network coherence for four higher-order cognitive resting-state networks on a sensitive measure of cognitive aging (i.e., NIH Toolbox Fluid Cognition Battery) in 154 healthy older adults with a mean age of 71 and education ranging between 12 years and 21 years (mean = 16). Only coherence within the cingulo-opercular network (CON) was significantly related to Fluid Cognition Composite scores, explaining more variance in scores than age and education. Furthermore, we mapped CON connectivity onto fluid cognitive subdomains that typically decline in advanced age. Greater CON connectivity was associated with better performance on episodic memory, attention, and executive function tasks. Overall, the present study provides evidence to propose CON coherence as a potential novel neural marker for nonpathological cognitive aging.
NoteOpen access journal
VersionFinal published version
Except where otherwise noted, this item's license is described as Copyright © 2020 Hausman, O’Shea, Kraft, Boutzoukas, Evangelista, Van Etten, Bharadwaj, Smith, Porges, Hishaw, Wu, DeKosky, Alexander, Marsiske, Cohen and Woods. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s)are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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