The Role of Resting-State Network Functional Connectivity in Cognitive Aging
Author
Hausman, Hanna KO'Shea, Andrew
Kraft, Jessica N
Boutzoukas, Emanuel M
Evangelista, Nicole D
Van Etten, Emily J
Bharadwaj, Pradyumna K
Smith, Samantha G
Porges, Eric
Hishaw, Georg A
Wu, Samuel
DeKosky, Steven
Alexander, Gene E
Marsiske, Michael
Cohen, Ronald
Woods, Adam J
Affiliation
Univ Arizona, Dept Psychol, McKnight Brain InstUniv Arizona, Coll Med, Dept Psychiat & Neurol
Univ Arizona, Dept Psychiat, Neurosci Grad Interdisciplinary Program
Univ Arizona, Dept Psychiat, Physiol Sci Grad Interdisciplinary Program
Univ Arizona, BIO5 Inst
Issue Date
2020-06-12
Metadata
Show full item recordPublisher
FRONTIERS MEDIA SACitation
Hausman HK, O’Shea A, Kraft JN, Boutzoukas EM, Evangelista ND, Van Etten EJ, Bharadwaj PK, Smith SG, Porges E, Hishaw GA, Wu S, DeKosky S, Alexander GE, Marsiske M, Cohen R and Woods AJ (2020) The Role of Resting-State Network Functional Connectivity in Cognitive Aging. Front. Aging Neurosci. 12:177. doi: 10.3389/fnagi.2020.00177Journal
FRONTIERS IN AGING NEUROSCIENCERights
Copyright © 2020 Hausman, O’Shea, Kraft, Boutzoukas, Evangelista, Van Etten, Bharadwaj, Smith, Porges, Hishaw, Wu, DeKosky, Alexander, Marsiske, Cohen and Woods. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Aging is associated with disruptions in the resting-state functional architecture of the brain. Previous studies have primarily focused on age-related declines in the default mode network (DMN) and its implications in Alzheimer's disease. However, due to mixed findings, it is unclear if changes in resting-state network functional connectivity are linked to cognitive decline in healthy older adults. In the present study, we evaluated the influence of intra-network coherence for four higher-order cognitive resting-state networks on a sensitive measure of cognitive aging (i.e., NIH Toolbox Fluid Cognition Battery) in 154 healthy older adults with a mean age of 71 and education ranging between 12 years and 21 years (mean = 16). Only coherence within the cingulo-opercular network (CON) was significantly related to Fluid Cognition Composite scores, explaining more variance in scores than age and education. Furthermore, we mapped CON connectivity onto fluid cognitive subdomains that typically decline in advanced age. Greater CON connectivity was associated with better performance on episodic memory, attention, and executive function tasks. Overall, the present study provides evidence to propose CON coherence as a potential novel neural marker for nonpathological cognitive aging.Note
Open access journalISSN
1663-4365PubMed ID
32595490Version
Final published versionae974a485f413a2113503eed53cd6c53
10.3389/fnagi.2020.00177
Scopus Count
Collections
Except where otherwise noted, this item's license is described as Copyright © 2020 Hausman, O’Shea, Kraft, Boutzoukas, Evangelista, Van Etten, Bharadwaj, Smith, Porges, Hishaw, Wu, DeKosky, Alexander, Marsiske, Cohen and Woods. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Related articles
- Brain Network Connectivity Mediates Education-related Cognitive Performance in Healthy Elderly Adults.
- Authors: Chen Y, Qi D, Qin T, Chen K, Ai M, Li X, Li H, Zhang J, Mao H, Yang Y, Zhang Z
- Issue date: 2019
- Effects of task complexity and age-differences on task-related functional connectivity of attentional networks.
- Authors: O'Connell MA, Basak C
- Issue date: 2018 Jun
- The Longitudinal Trajectory of Default Mode Network Connectivity in Healthy Older Adults Varies As a Function of Age and Is Associated with Changes in Episodic Memory and Processing Speed.
- Authors: Staffaroni AM, Brown JA, Casaletto KB, Elahi FM, Deng J, Neuhaus J, Cobigo Y, Mumford PS, Walters S, Saloner R, Karydas A, Coppola G, Rosen HJ, Miller BL, Seeley WW, Kramer JH
- Issue date: 2018 Mar 14
- Higher-order resting state network association with the useful field of view task in older adults.
- Authors: Hardcastle C, Hausman HK, Kraft JN, Albizu A, Evangelista ND, Boutzoukas EM, O'Shea A, Langer K, Van Van Etten E, Bharadwaj PK, Song H, Smith SG, Porges E, DeKosky ST, Hishaw GA, Wu SS, Marsiske M, Cohen R, Alexander GE, Woods AJ
- Issue date: 2022 Feb
- Functional Connectivity Dynamics Altered of the Resting Brain in Subjective Cognitive Decline.
- Authors: Wei YC, Kung YC, Huang WY, Lin C, Chen YL, Chen CK, Shyu YC, Lin CP
- Issue date: 2022