Cell-Free DNA as an Addition to Ultrasound for Screening of a Complete Hydatidiform Mole and Coexisting Normal Fetus Pregnancy: A Case Report
Affiliation
Univ Arizona, Banner Univ Med Ctr, Dept Obstet & GynecolIssue Date
2020-06-18Keywords
complete hydatidiform mole and coexisting normal fetuscell-free DNA
twin-molar pregnancy
hyperemesis gravidarum
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THIEME MEDICAL PUBL INCCitation
Gabra, M. G., Gonzalez, M. G., Bullock, H. N., & Hill, M. G. (2020). Cell-Free DNA as an Addition to Ultrasound for Screening of a Complete Hydatidiform Mole and Coexisting Normal Fetus Pregnancy: A Case Report. AJP reports, 10(2), e176.Journal
AJP REPORTSRights
Copyright © 2020 by Thieme Medical Publishers, Inc. License terms: CC BY-NC-ND 4.0.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Background: Complete hydatidiform mole and coexisting normal fetus pregnancies (CHMCF) are rare and can be life-threatening to the mother. Definitive diagnosis can be made with chorionic villus sampling or amniocentesis. However invasive procedures carry a risk of bleeding. We present the case of a twin molar pregnancy where a cell-free DNA screening test was utilized to evaluate for CHMCF pregnancy. Case: A patient presented at 15-week gestational age with suspected CHMCF pregnancy. Ultrasound revealed a normal-appearing pregnancy abutting a multicystic lesion concerning for a complete mole. Cell-free DNA was obtained and was suggestive of complete paternal uniparental disomy. Pathological evaluation of the products of conception confirmed the diagnosis of CHMCF. Conclusion: In atypical cases, cell-free DNA may be useful in evaluation of molar pregnancy.Note
Open access journalISSN
2157-6998PubMed ID
32566367Version
Final published versionae974a485f413a2113503eed53cd6c53
10.1055/s-0040-1709981
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Except where otherwise noted, this item's license is described as Copyright © 2020 by Thieme Medical Publishers, Inc. License terms: CC BY-NC-ND 4.0.
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