Cell-Free DNA as an Addition to Ultrasound for Screening of a Complete Hydatidiform Mole and Coexisting Normal Fetus Pregnancy: A Case Report
AffiliationUniv Arizona, Banner Univ Med Ctr, Dept Obstet & Gynecol
Keywordscomplete hydatidiform mole and coexisting normal fetus
MetadataShow full item record
PublisherTHIEME MEDICAL PUBL INC
CitationGabra, M. G., Gonzalez, M. G., Bullock, H. N., & Hill, M. G. (2020). Cell-Free DNA as an Addition to Ultrasound for Screening of a Complete Hydatidiform Mole and Coexisting Normal Fetus Pregnancy: A Case Report. AJP reports, 10(2), e176.
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AbstractBackground: Complete hydatidiform mole and coexisting normal fetus pregnancies (CHMCF) are rare and can be life-threatening to the mother. Definitive diagnosis can be made with chorionic villus sampling or amniocentesis. However invasive procedures carry a risk of bleeding. We present the case of a twin molar pregnancy where a cell-free DNA screening test was utilized to evaluate for CHMCF pregnancy. Case: A patient presented at 15-week gestational age with suspected CHMCF pregnancy. Ultrasound revealed a normal-appearing pregnancy abutting a multicystic lesion concerning for a complete mole. Cell-free DNA was obtained and was suggestive of complete paternal uniparental disomy. Pathological evaluation of the products of conception confirmed the diagnosis of CHMCF. Conclusion: In atypical cases, cell-free DNA may be useful in evaluation of molar pregnancy.
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VersionFinal published version
Except where otherwise noted, this item's license is described as Copyright © 2020 by Thieme Medical Publishers, Inc. License terms: CC BY-NC-ND 4.0.
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