Approach to High Volume Enrollment in Clinical Research: Experiences from an All of Us Research Program Site
AuthorIlori, Titilayo O
StimsonRiahi, Sara C
Karnes, Jason H
AffiliationUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Div Publ Hlth Practice & Translat Res
Univ Arizona, Coll Med, Dept Psychiat
Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Hlth Promot Sci
Univ Arizona Hlth Sci
Univ Arizona, Dept Med
Univ Arizona, Dept Med, Coll Med Phoenix
Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Div Community Environm & Policy
Univ Arizona, Coll Pharm, Dept Pharm Practice & Sci
Univ Arizona, Dept Pediat
MetadataShow full item record
CitationIlori, T. O., Viera, E., Wilson, J., Moreno, F., Menon, U., Ehiri, J., ... & Ojo, T. (2020). Approach to High Volume Enrollment in Clinical Research: Experiences from an All of Us Research Program Site. Clinical and Translational Science.
Rights© 2020 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractClinical trials and cohort studies are required to meet target recruitment of study participants within stipulated timelines, especially when the priority is to include populations traditionally unrepresented in biomedical research. By the third quarter of 2019, the University of Arizona-Banner Health Provider Organization (UA-Banner HPO) has enrolled > 30,000 core participants into theAll of UsResearch Program (AoURP), the research cohort of the Precision Medicine Initiative. The majority of enrolled participants meet the criteria for individuals under-represented in biomedical research. The enrollment goals were calculated based on a target of 20,000 as set by the National Institutes of Health and our health provider organization achieved enrollment numbers between 17% and 86% above the targeted daily enrollment. We evaluated enrollment methods and challenges to enrollments encountered by the UA-Banner Health Provider Organization into theAoURP. Challenges to enrollment centered around the need for high-touch engagement methods, time investment necessary for stakeholder inclusion, and the use of purely digital enrollment methods especially in populations under-represented in biomedical research. These challenges occurred at the level of the individual, provider, institutions, and community, and cumulatively impacted participant enrollment. Successful strategies for engagement and enrollment leveraged provider partners as advocates for the program. For high-volume enrollment in clinical research, it is important to engage leaders in the healthcare setting, patient providers, and tailor engagement and enrollment to potential participant needs. We emphasize the need for precision engagement and enrollment methods tailored to individual needs.
NoteOpen access journal
VersionFinal published version
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