Randomized Pilot Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation: The PEARL Study
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Final Accepted Manuscript
Author
Kern, Karl BRadsel, Peter
Jentzer, Jacob C
Seder, David B
Lee, Kwan S
Lotun, Kapildeo
Janardhanan, Rajesh
Stub, Dion
Hsu, Chiu-Hsieh
Noc, Marko
Affiliation
Univ Arizona, Dept Med, Sarver Heart CtrUniv Arizona, Coll Publ Hlth
Issue Date
2020-09-28
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LIPPINCOTT WILLIAMS & WILKINSCitation
Kern, K. B., Radsel, P., Jentzer, J. C., Seder, D. B., Lee, K. S., Lotun, K., ... & Noc, M. (2020). Randomized pilot clinical trial of early coronary angiography versus no early coronary angiography after cardiac arrest without ST-segment elevation: the PEARL study. Circulation, 142(21), 2002-2012.Journal
CIRCULATIONRights
© 2020 American Heart Association, Inc.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
The study was terminated prematurely before enrolling the target number of patients. A total of 99 patients were enrolled from 2015 to 2018, including 75 with initially shockable rhythms. Forty-nine patients were randomized to early coronary angiography. The primary end point of efficacy and safety was not different between the 2 groups (55.1% versus 46.0%; P=0.64). Early coronary angiography was not associated with any significant increase in survival (55.1% versus 48.0%; P=0.55) or adverse events (26.5% versus 26.0%; P=1.00). Early coronary angiography revealed a culprit vessel in 47%, with a total of 14% of patients undergoing early coronary angiography having an acutely occluded culprit coronary artery.Note
12 month embargo; published 28 September 2020ISSN
0009-7322EISSN
1524-4539PubMed ID
32985249Version
Final accepted manuscriptae974a485f413a2113503eed53cd6c53
10.1161/CIRCULATIONAHA.120.049569
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