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    Randomized Pilot Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation: The PEARL Study

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    Author
    Kern, Karl B
    Radsel, Peter
    Jentzer, Jacob C
    Seder, David B
    Lee, Kwan S
    Lotun, Kapildeo
    Janardhanan, Rajesh
    Stub, Dion
    Hsu, Chiu-Hsieh
    Noc, Marko
    Affiliation
    Univ Arizona, Dept Med, Sarver Heart Ctr
    Univ Arizona, Coll Publ Hlth
    Issue Date
    2020-09-28
    Keywords
    coronary angiography
    heart arrest
    Out-of-hospital cardiac arrest
    
    Metadata
    Show full item record
    Publisher
    LIPPINCOTT WILLIAMS & WILKINS
    Citation
    Kern, K. B., Radsel, P., Jentzer, J. C., Seder, D. B., Lee, K. S., Lotun, K., ... & Noc, M. (2020). Randomized pilot clinical trial of early coronary angiography versus no early coronary angiography after cardiac arrest without ST-segment elevation: the PEARL study. Circulation, 142(21), 2002-2012.
    Journal
    CIRCULATION
    Rights
    © 2020 American Heart Association, Inc.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The study was terminated prematurely before enrolling the target number of patients. A total of 99 patients were enrolled from 2015 to 2018, including 75 with initially shockable rhythms. Forty-nine patients were randomized to early coronary angiography. The primary end point of efficacy and safety was not different between the 2 groups (55.1% versus 46.0%; P=0.64). Early coronary angiography was not associated with any significant increase in survival (55.1% versus 48.0%; P=0.55) or adverse events (26.5% versus 26.0%; P=1.00). Early coronary angiography revealed a culprit vessel in 47%, with a total of 14% of patients undergoing early coronary angiography having an acutely occluded culprit coronary artery.
    Note
    12 month embargo; published 28 September 2020
    ISSN
    0009-7322
    EISSN
    1524-4539
    PubMed ID
    32985249
    DOI
    10.1161/CIRCULATIONAHA.120.049569
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1161/CIRCULATIONAHA.120.049569
    Scopus Count
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    UA Faculty Publications

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