Randomized Pilot Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation: The PEARL Study
AuthorKern, Karl B
Jentzer, Jacob C
Seder, David B
Lee, Kwan S
AffiliationUniv Arizona, Dept Med, Sarver Heart Ctr
Univ Arizona, Coll Publ Hlth
MetadataShow full item record
PublisherLIPPINCOTT WILLIAMS & WILKINS
CitationKern, K. B., Radsel, P., Jentzer, J. C., Seder, D. B., Lee, K. S., Lotun, K., ... & Noc, M. (2020). Randomized pilot clinical trial of early coronary angiography versus no early coronary angiography after cardiac arrest without ST-segment elevation: the PEARL study. Circulation, 142(21), 2002-2012.
Rights© 2020 American Heart Association, Inc.
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AbstractThe study was terminated prematurely before enrolling the target number of patients. A total of 99 patients were enrolled from 2015 to 2018, including 75 with initially shockable rhythms. Forty-nine patients were randomized to early coronary angiography. The primary end point of efficacy and safety was not different between the 2 groups (55.1% versus 46.0%; P=0.64). Early coronary angiography was not associated with any significant increase in survival (55.1% versus 48.0%; P=0.55) or adverse events (26.5% versus 26.0%; P=1.00). Early coronary angiography revealed a culprit vessel in 47%, with a total of 14% of patients undergoing early coronary angiography having an acutely occluded culprit coronary artery.
Note12 month embargo; published 28 September 2020
VersionFinal accepted manuscript