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dc.contributor.authorGnanadesikan, Gitanjali E
dc.contributor.authorHare, Brian
dc.contributor.authorSnyder-Mackler, Noah
dc.contributor.authorCall, Josep
dc.contributor.authorKaminski, Juliane
dc.contributor.authorMiklósi, Ádám
dc.contributor.authorMacLean, Evan L
dc.date.accessioned2021-01-13T00:41:45Z
dc.date.available2021-01-13T00:41:45Z
dc.date.issued2020-10
dc.identifier.citationGitanjali E Gnanadesikan, Brian Hare, Noah Snyder-Mackler, Josep Call, Juliane Kaminski, Ádám Miklósi, Evan L MacLean, Breed Differences in Dog Cognition Associated with Brain-Expressed Genes and Neurological Functions, Integrative and Comparative Biology, Volume 60, Issue 4, October 2020, Pages 976–990, https://doi.org/10.1093/icb/icaa112en_US
dc.identifier.issn1540-7063
dc.identifier.pmid32726413
dc.identifier.doi10.1093/icb/icaa112
dc.identifier.urihttp://hdl.handle.net/10150/650732
dc.description.abstractGiven their remarkable phenotypic diversity, dogs present a unique opportunity for investigating the genetic bases of cognitive and behavioral traits. Our previous work demonstrated that genetic relatedness among breeds accounts for a substantial portion of variation in dog cognition. Here, we investigated the genetic architecture of breed differences in cognition, seeking to identify genes that contribute to variation in cognitive phenotypes. To do so, we combined cognitive data from the citizen science project Dognition. com with published breed-average genetic polymorphism data, resulting in a dataset of 1654 individuals with cognitive phenotypes representing 49 breeds. We conducted a breedaverage genome-wide association study to identify specific polymorphisms associated with breed differences in inhibitory control, communication, memory, and physical reasoning. We found five single nucleotide polymorphisms (SNPs) that reached genome-wide significance after Bonferroni correction, located in EML1, OR52E2, HS3ST5, a U6 spliceosomal RNA, and a long noncoding RNA. When we combined results across multiple SNPs within the same gene, we identified 188 genes implicated in breed differences in cognition. This gene set included more genes than expected by chance that were (1) differentially expressed in brain tissue and (2) involved in nervous system functions including peripheral nervous system development, Wnt signaling, presynapse assembly, and synaptic vesicle exocytosis. These results advance our understanding of the genetic underpinnings of complex cognitive phenotypes and identify specific genetic variants for further research.en_US
dc.language.isoenen_US
dc.publisherOXFORD UNIV PRESS INCen_US
dc.rights© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.titleBreed Differences in Dog Cognition Associated with Brain-Expressed Genes and Neurological Functionsen_US
dc.typeArticleen_US
dc.identifier.eissn1557-7023
dc.contributor.departmentUniv Arizona, Sch Anthropolen_US
dc.contributor.departmentUniv Arizona, Cognit Sci Programen_US
dc.contributor.departmentUniv Arizona, Psychol Depten_US
dc.contributor.departmentUniv Arizona, Coll Vet Meden_US
dc.identifier.journalIntegrative and comparative biologyen_US
dc.description.note12 month embargo; published 01 October 2020en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleIntegrative and comparative biology
dc.source.volume60
dc.source.issue4
dc.source.beginpage976
dc.source.endpage990
dc.source.countryUnited States
dc.source.countryEngland


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