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    A PRECISION BRACHYTHERAPY DEVICE FOR THE TREATMENT OF ESOPHAGEAL CANCER

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    Author
    Zenhausern, Ryan
    Issue Date
    2020-05
    Advisor
    Redford, Gary
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Project goal:​​ To design a precise brachytherapy device to deliver twice the radiation dose to cancerous tissue than to healthy tissue for patients with esophageal cancer. Brachytherapy is a form of radiation therapy in which a small radioactive seed is placed in close proximity to cancerous tissue in order to minimize damage to the healthy surrounding tissue. Non-specific brachytherapy exposure minimizes both treatment efficacy and maximum applied dose in the treatment of esophageal cancers. A precision brachytherapy device was sought after to improve patient care. A precision brachytherapy device utilizing multiple seed channels was created using materials compatible with gamma radiation used during the procedure, ethylene oxide for sterilization of the device, and diluted acid to simulate the conditions of the esophageal tract. Water and contrast mixture, used for visualization during a CT scan, were used to fill balloons which function to stabilize the device. The multiple seed channels were compatible with existing brachytherapy equipment and the device does not require additional training of radiation oncologists or medical physicists. Analysis proved that the device achieves twice the dose of radiation to cancerous tissue than healthy tissue in patients.
    Type
    Electronic Thesis
    text
    Degree Name
    B.S.
    Degree Level
    bachelors
    Degree Program
    Biomedical Engineering
    Honors College
    Degree Grantor
    University of Arizona
    Collections
    Honors Theses

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