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dc.contributor.authorWu, X. H.
dc.contributor.authorWang, H. F.
dc.contributor.authorLiu, Y. F.
dc.contributor.authorLu, X. Y.
dc.contributor.authorWang, J. J. J.
dc.contributor.authorLi, K.
dc.date.accessioned2021-02-11T20:44:33Z
dc.date.available2021-02-11T20:44:33Z
dc.date.issued1997-01-01
dc.identifier.citationWu, X. H., Wang, H. F., Liu, Y. F., Lu, X. Y., Wang, J. J., & Li, K. (1997). Histone adduction with nicotine: A bio-AMS study. Radiocarbon, 39(3), 293-297.
dc.identifier.issn0033-8222
dc.identifier.doi10.1017/S0033822200053273
dc.identifier.urihttp://hdl.handle.net/10150/653622
dc.description.abstractBased on the study of DNA adduction with nicotine, we have measured the mouse hepatic histone adduction with 14C-labeled nicotine in vivo by bio-accelerator mass spectrometry (bio-AMS). In the exposure of mice to nicotine, the dose range administered was from 0.2 micrograms to 6.0 micrograms kg b.w.-1, which was equivalent to a very low level of human exposure to cigarette smoke. The adducts of either histone 1(H1) or histone 3 (H3) with nicotine in mouse liver increased markedly with increasing nicotine dose. Our results have demonstrated that in the study of protein adduction with toxic xenobiotics as a biomarker, the AMS method achieves the highest sensitivity, 4.6x 10^-17 mol (46 amol) adducts per mg Hl protein, compared to all the other methods used previously.
dc.language.isoen
dc.publisherDepartment of Geosciences, The University of Arizona
dc.relation.urlhttp://radiocarbon.webhost.uits.arizona.edu/
dc.rightsCopyright © by the Arizona Board of Regents on behalf of the University of Arizona. All rights reserved.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleHistone Adduction with Nicotine: A Bio-AMS Study
dc.typeArticle
dc.typetext
dc.identifier.journalRadiocarbon
dc.description.noteThis material was digitized as part of a cooperative project between Radiocarbon and the University of Arizona Libraries.
dc.description.collectioninformationThe Radiocarbon archives are made available by Radiocarbon and the University of Arizona Libraries. Contact lbry-journals@email.arizona.edu for further information.
dc.eprint.versionFinal published version
dc.description.admin-noteMigrated from OJS platform February 2021
dc.source.volume39
dc.source.issue3
dc.source.beginpage293
dc.source.endpage297
refterms.dateFOA2021-02-11T20:44:33Z


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