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dc.contributor.authorMohzari, Yahya
dc.contributor.authorAljobair, Fahad
dc.contributor.authorAlrashed, Ahmed
dc.contributor.authorAsdaq, Syed Mohammed Basheeruddin
dc.contributor.authorAlshuraim, Renad Abdullah
dc.contributor.authorAsfour, Suzan Suhail
dc.contributor.authorAl-Mouqdad, Mountasser Mohammad
dc.contributor.authorBamogaddam, Reem F.
dc.contributor.authorAl-Anazi, Deemah
dc.contributor.authorZeilinger, Catherine E.
dc.contributor.authorAlamer, Ahmad
dc.contributor.authorAlhassan, Batool Mohammed
dc.contributor.authorSreeharsha, Nagaraja
dc.date.accessioned2021-03-24T21:10:46Z
dc.date.available2021-03-24T21:10:46Z
dc.date.issued2021-02-07
dc.identifier.citationMohzari, Y., Aljobair, F., Alrashed, A., Asdaq, S. M. B., Alshuraim, R. A., Asfour, S. S., ... & Sreeharsha, N. (2021). Safety and Efficacy of Daptomycin in Neonates with Coagulase-Negative Staphylococci: Case Series Analysis. Antibiotics, 10(2), 168.en_US
dc.identifier.issn2079-6382
dc.identifier.doi10.3390/antibiotics10020168
dc.identifier.urihttp://hdl.handle.net/10150/657193
dc.description.abstractThere has been an increase in the prevalence of gram-positive bacteremia in neonates in the last two decades. However, as a consequence of better care, there has been an increase in the survival of premature neonates. Coagulase-negative staphylococci (CoNS) is the most prevalent bacteria, responsible for up to 60% of late-onset sepsis (LOS). Daptomycin, a lipopeptide antimicrobial agent, is active against CoNS. This was an observational, retrospective case series study carried out in the Pediatric Hospital of King Saud Medical City, Riyadh, Saudi Arabia. The medical records of 21 neonates, aged 0–28 days, who were treated in Neonatal Intensive Care Unit (NICU) with intravenous daptomycin as monotherapy or combination therapy for at least 4 days for proven gram-positive infection between June 2019 to July 2020, were included. The median gestational and chronological age were 27 weeks and 5 days, respectively. The most frequent diagnosis in neonates was infective endocarditis (42.9%). Of the 21 patients who received daptomycin therapy, 13 (62%) recovered and 8 died. The clinical cure rate was higher in Staphylococcus hominis (100%) and in patients who received 6 mg/kg/dose twice daily (62.5%). The mean of aspartate aminotransferase significantly elevated after starting daptomycin (p = 0.048). However, no muscular or neurological toxicity of daptomycin was documented in any of the cases. Overall, daptomycin was well tolerated, even with long-term treatment. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectCoagulase-negative staphylococcien_US
dc.subjectDaptomycinen_US
dc.subjectEfficacyen_US
dc.subjectNeonatesen_US
dc.subjectRetrospectiveen_US
dc.subjectSafetyen_US
dc.titleSafety and Efficacy of Daptomycin in Neonates with Coagulase-Negative Staphylococci: Case Series Analysisen_US
dc.typeArticleen_US
dc.identifier.eissn2079-6382
dc.contributor.departmentCenter for Health Outcomes and PharmacoEconomic Research, University of Arizonaen_US
dc.identifier.journalAntibioticsen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleAntibiotics
dc.source.volume10
dc.source.issue2
dc.source.beginpage168
refterms.dateFOA2021-03-24T21:10:47Z


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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).