Infrared neural stimulation with 7T fMRI: A rapid in vivo method for mapping cortical connections of primate amygdala
Name:
Shi et al., 2021 Neuroimage.pdf
Size:
3.961Mb
Format:
PDF
Description:
Final Published Version
Author
Shi, SunhangXu, Augix Guohua
Rui, Yun-Yun
Zhang, Xiaotong
Romanski, Lizabeth M
Gothard, Katalin M
Roe, Anna Wang
Affiliation
Dept of Physiology, University of ArizonaIssue Date
2021-02-04Keywords
Basal nucleus of the amygdalaConnectome
Functional tract tracing
High spatial resolution
Infrared neural stimulation
Macaque monkey
Mesoscale
Metadata
Show full item recordPublisher
Academic Press Inc.Citation
Shi, S., Xu, A. G., Rui, Y. Y., Zhang, X., Romanski, L. M., Gothard, K. M., & Roe, A. W. (2021). Infrared neural stimulation with 7T fMRI: A rapid in vivo method for mapping cortical connections of primate amygdala. NeuroImage, 231, 117818.Journal
NeuroImageRights
Copyright © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
We have previously shown that INS-fMRI is a rapid method for mapping mesoscale brain networks in the macaque monkey brain. Focal stimulation of single cortical sites led to the activation of connected cortical locations, resulting in a global connectivity map. Here, we have extended this method for mapping brainwide networks following stimulation of single subcortical sites. As a testbed, we focused on the basal nucleus of the amygdala in the macaque monkey. We describe methods to target basal nucleus locations with submillimeter precision, pulse train stimulation methods, and statistical tests for assessing non-random nature of activations. Using these methods, we report that stimulation of precisely targeted loci in the basal nucleus produced sparse and specific activations in the brain. Activations were observed in the insular and sensory association cortices as well as activations in the cingulate cortex, consistent with known anatomical connections. What is new here is that the activations were focal and, in some cases, exhibited shifting topography with millimeter shifts in stimulation site. The precision of the method enables networks mapped from different nearby sites in the basal nucleus to be distinguished. While further investigation is needed to improve the sensitivity of this method, our analyses do support the reproducibility and non-random nature of some of the activations. We suggest that INS-fMRI is a promising method for mapping large-scale cortical and subcortical networks at high spatial resolution. © 2021 The Author(s)Note
Open access articleISSN
1053-8119EISSN
1095-9572PubMed ID
33548458Version
Final published versionae974a485f413a2113503eed53cd6c53
10.1016/j.neuroimage.2021.117818
Scopus Count
Collections
Except where otherwise noted, this item's license is described as Copyright © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).