Longitudinal evaluation of whole blood miRNA expression in firefighters
AuthorJung, Alesia M.
Beitel, Shawn C.
Littau, Sally R.
Gulotta, John J.
Wallentine, Darin D.
Moore, Paul K.
Burgess, Jefferey L.
AffiliationDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona
Department of Community, Environment and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona
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CitationJung, A. M., Zhou, J., Beitel, S. C., Littau, S. R., Gulotta, J. J., Wallentine, D. D., ... & Burgess, J. L. (2021). Longitudinal evaluation of whole blood miRNA expression in firefighters. Journal of Exposure Science & Environmental Epidemiology, 1-13.
Rights© The Author(s) 2021. This article is published with open access. This article is licensed under a Creative Commons Attribution 4.0 International License.
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AbstractBackground: Dysregulated microRNA (miRNA) expression could provide a mechanism linking firefighter exposure to increased cancer risk. Objective: To determine if changes in longitudinal miRNA expression in firefighters are associated with occupational exposures. Methods: Whole blood MiRNA was evaluated in 52 new recruits prior to live-fire training and 20–37 months later. Linear mixed effects models adjusted for age, ethnicity, BMI, and batch effects were used to determine associations separately for all fires and structure fires only between employment duration, cumulative fire-hours and fire-runs, and time since most recent fire with (1) nine a priori and (2) the full array of 799 miRNAs. Results: For multivariable models including all fires, two a priori miRNAs were associated with employment duration and four with time since most recent fire. For multivariable models restricted to structure fires, three a priori miRNAs were associated with employment duration and one with fire-runs. Additional miRNAs from the full array were associated with employment duration for all fires and/or structure fires. In general, tumor suppressive miRNAs decreased and oncogenic miRNAs increased with exposure. Significance: Changes in miRNAs may serve as biomarkers of exposure effects and a mechanism for increased cancer risk in firefighters. © 2021, The Author(s).
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Except where otherwise noted, this item's license is described as © The Author(s) 2021. This article is published with open access. This article is licensed under a Creative Commons Attribution 4.0 International License.