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dc.contributor.authorZhou, Tong
dc.contributor.authorXie, Xueying
dc.contributor.authorLi, Musheng
dc.contributor.authorShi, Junchao
dc.contributor.authorZhou, Jin J
dc.contributor.authorKnox, Kenneth S
dc.contributor.authorWang, Ting
dc.contributor.authorChen, Qi
dc.contributor.authorGu, Wanjun
dc.date.accessioned2021-04-01T21:26:04Z
dc.date.available2021-04-01T21:26:04Z
dc.date.issued2018-08-09
dc.identifier.citationZhou, T., Xie, X., Li, M., Shi, J., Zhou, J. J., Knox, K. S., ... & Gu, W. (2018). Rat BodyMap transcriptomes reveal unique circular RNA features across tissue types and developmental stages. Rna, 24(11), 1443-1456.en_US
dc.identifier.issn1355-8382
dc.identifier.pmid30093490
dc.identifier.doi10.1261/rna.067132.118
dc.identifier.urihttp://hdl.handle.net/10150/657290
dc.description.abstractCircular RNAs (circRNAs) are a novel class of regulatory RNAs. Here, we present a comprehensive investigation of circRNA expression profiles across 11 tissues and four developmental stages in rats, along with cross-species analyses in humans and mice. Although the expression of circRNAs is positively correlated with that of cognate mRNAs, highly expressed genes tend to splice a larger fraction of circular transcripts. Moreover, circRNAs exhibit higher tissue specificity than cognate mRNAs. Intriguingly, while we observed a monotonic increase of circRNA abundance with age in the rat brain, we further discovered a dynamic, age-dependent pattern of circRNA expression in the testes that is characterized by a dramatic increase with advancing stages of sexual maturity and a decrease with aging. The age-sensitive testicular circRNAs are highly associated with spermatogenesis, independent of cognate mRNA expression. The tissue/age implications of circRNAs suggest that they present unique physiological functions rather than simply occurring as occasional by-products of gene transcription.en_US
dc.language.isoenen_US
dc.publisherCOLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPTen_US
dc.rights© 2018 Zhou et al. This article, published in RNA, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectcircRNA expressionen_US
dc.subjecttestis functionen_US
dc.subjecttissue specificityen_US
dc.subjectage-dependent expressionen_US
dc.titleRat BodyMap transcriptomes reveal unique circular RNA features across tissue types and developmental stagesen_US
dc.typeArticleen_US
dc.identifier.eissn1469-9001
dc.contributor.departmentUniv Arizona, Dept Epidemiol & Biostaten_US
dc.contributor.departmentUniv Arizona, Coll Med Phoenix, Dept Internal Meden_US
dc.identifier.journalRNAen_US
dc.description.noteOpen access articleen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleRNA (New York, N.Y.)
dc.source.volume24
dc.source.issue11
dc.source.beginpage1443
dc.source.endpage1456
refterms.dateFOA2021-04-01T21:26:14Z
dc.source.countryUnited States
dc.source.countryUnited States


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© 2018 Zhou et al. This article, published in RNA, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's license is described as © 2018 Zhou et al. This article, published in RNA, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.