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    The complex role of prostaglandin E-EP receptor signaling in wound healing

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    PGE2_review_FINAL.pdf
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    Author
    Gilman, Kristy E
    Limesand, Kirsten H
    Affiliation
    Department of Nutritional Sciences, University of Arizona
    Issue Date
    2020-12-09
    Keywords
    cell signaling
    Prostaglandins
    repair
    tissue damage
    wound healing
    
    Metadata
    Show full item record
    Publisher
    American Physiological Society
    Citation
    Gilman, K. E., & Limesand, K. H. (2020). The complex role of Prostaglandin E2-EP receptor signaling in wound healing. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.
    Journal
    American journal of physiology. Regulatory, integrative and comparative physiology
    Rights
    Copyright © 2021 the American Physiological Society.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E2 (PGE2) being the most complex and exhibiting the most diverse physiological outputs. PGE2 signals via four G protein-coupled receptors, termed EP-receptors 1-4 that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE2 and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.
    Note
    12 month embargo; first published online 9 December 2020
    ISSN
    1522-1490
    EISSN
    1522-1490
    PubMed ID
    33296281
    DOI
    10.1152/ajpregu.00185.2020
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1152/ajpregu.00185.2020
    Scopus Count
    Collections
    UA Faculty Publications

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