The complex role of prostaglandin E-EP receptor signaling in wound healing
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PGE2_review_FINAL.pdf
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Final Accepted Manuscript
Affiliation
Department of Nutritional Sciences, University of ArizonaIssue Date
2020-12-09
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American Physiological SocietyCitation
Gilman, K. E., & Limesand, K. H. (2020). The complex role of Prostaglandin E2-EP receptor signaling in wound healing. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.Rights
Copyright © 2021 the American Physiological Society.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E2 (PGE2) being the most complex and exhibiting the most diverse physiological outputs. PGE2 signals via four G protein-coupled receptors, termed EP-receptors 1-4 that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE2 and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.Note
12 month embargo; first published online 9 December 2020ISSN
1522-1490EISSN
1522-1490PubMed ID
33296281Version
Final accepted manuscriptae974a485f413a2113503eed53cd6c53
10.1152/ajpregu.00185.2020
