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    Rapid high-resolution volumetric T mapping using a highly accelerated stack-of-stars Look Locker technique

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    Name:
    Altbach_UA_open_access_version.pdf
    Embargo:
    2022-03-22
    Size:
    2.293Mb
    Format:
    PDF
    Description:
    Final Accepted Manuscript
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    Author
    Li, Zhitao
    Fu, Zhiyang
    Keerthivasan, Mahesh
    Bilgin, Ali
    Johnson, Kevin
    Galons, Jean-Philippe
    Vedantham, Srinivasan
    Martin, Diego R
    Altbach, Maria I
    Affiliation
    Department of Electrical and Computer Engineering, the University of Arizona
    Department of Medical Imaging, the University of Arizona
    Department of Biomedical Engineering, the University of Arizona
    Issue Date
    2021-03-03
    Keywords
    3D radial MRI
    Look-Locker method
    Model-based
    T(1)
    T(1) mapping
    
    Metadata
    Show full item record
    Publisher
    Elsevier Inc.
    Citation
    Li, Z., Fu, Z., Keerthivasan, M., Bilgin, A., Johnson, K., Galons, J. P., ... & Altbach, M. I. (2021). Rapid high-resolution volumetric T1 mapping using a highly accelerated stack-of-stars Look Locker technique. Magnetic Resonance Imaging.
    Journal
    Magnetic Resonance Imaging
    Rights
    Copyright © 2021 Elsevier Inc. All rights reserved.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Purpose: To develop a fast volumetric T1 mapping technique. Materials and methods: A stack-of-stars (SOS) Look Locker technique based on the acquisition of undersampled radial data (>30× relative to Nyquist) and an efficient multi-slab excitation scheme is presented. A principal-component based reconstruction is used to reconstruct T1 maps. Computer simulations were performed to determine the best choice of partitions per slab and degree of undersampling. The technique was validated in phantoms against reference T1 values measured with a 2D Cartesian inversion-recovery spin-echo technique. The SOS Look Locker technique was tested in brain (n = 4) and prostate (n = 5). Brain T1 mapping was carried out with and without kz acceleration and results between the two approaches were compared. Prostate T1 mapping was compared to standard techniques. A reproducibility study was conducted in brain and prostate. Statistical analyses were performed using linear regression and Bland Altman analysis. Results: Phantom T1 values showed excellent correlations between SOS Look Locker and the inversion-recovery spin-echo reference (r2 = 0.9965; p < 0.0001) and between SOS Look Locker with slab-selective and non-slab selective inversion pulses (r2 = 0.9999; p < 0.0001). In vivo results showed that full brain T1 mapping (1 mm3) with kz acceleration is achieved in 4 min 21 s. Full prostate T1 mapping (0.9 × 0.9 × 4 mm3) is achieved in 2 min 43 s. T1 values for brain and prostate were in agreement with literature values. A reproducibility study showed coefficients of variation in the range of 0.18–0.2% (brain) and 0.15–0.18% (prostate). Conclusion: A rapid volumetric T1 mapping technique was developed. The technique enables high-resolution T1 mapping with adequate anatomical coverage in a clinically acceptable time. © 2021 Elsevier Inc.
    Note
    12 month embargo; first published online 22 March 2021
    ISSN
    0730-725X
    EISSN
    1873-5894
    PubMed ID
    33722634
    DOI
    10.1016/j.mri.2021.03.003
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.mri.2021.03.003
    Scopus Count
    Collections
    UA Faculty Publications

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