Rapid high-resolution volumetric T mapping using a highly accelerated stack-of-stars Look Locker technique
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2022-03-22
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Final Accepted Manuscript
Author
Li, ZhitaoFu, Zhiyang
Keerthivasan, Mahesh
Bilgin, Ali
Johnson, Kevin
Galons, Jean-Philippe
Vedantham, Srinivasan
Martin, Diego R
Altbach, Maria I
Affiliation
Department of Electrical and Computer Engineering, the University of ArizonaDepartment of Medical Imaging, the University of Arizona
Department of Biomedical Engineering, the University of Arizona
Issue Date
2021-03-03
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Elsevier Inc.Citation
Li, Z., Fu, Z., Keerthivasan, M., Bilgin, A., Johnson, K., Galons, J. P., ... & Altbach, M. I. (2021). Rapid high-resolution volumetric T1 mapping using a highly accelerated stack-of-stars Look Locker technique. Magnetic Resonance Imaging.Journal
Magnetic Resonance ImagingRights
Copyright © 2021 Elsevier Inc. All rights reserved.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Purpose: To develop a fast volumetric T1 mapping technique. Materials and methods: A stack-of-stars (SOS) Look Locker technique based on the acquisition of undersampled radial data (>30× relative to Nyquist) and an efficient multi-slab excitation scheme is presented. A principal-component based reconstruction is used to reconstruct T1 maps. Computer simulations were performed to determine the best choice of partitions per slab and degree of undersampling. The technique was validated in phantoms against reference T1 values measured with a 2D Cartesian inversion-recovery spin-echo technique. The SOS Look Locker technique was tested in brain (n = 4) and prostate (n = 5). Brain T1 mapping was carried out with and without kz acceleration and results between the two approaches were compared. Prostate T1 mapping was compared to standard techniques. A reproducibility study was conducted in brain and prostate. Statistical analyses were performed using linear regression and Bland Altman analysis. Results: Phantom T1 values showed excellent correlations between SOS Look Locker and the inversion-recovery spin-echo reference (r2 = 0.9965; p < 0.0001) and between SOS Look Locker with slab-selective and non-slab selective inversion pulses (r2 = 0.9999; p < 0.0001). In vivo results showed that full brain T1 mapping (1 mm3) with kz acceleration is achieved in 4 min 21 s. Full prostate T1 mapping (0.9 × 0.9 × 4 mm3) is achieved in 2 min 43 s. T1 values for brain and prostate were in agreement with literature values. A reproducibility study showed coefficients of variation in the range of 0.18–0.2% (brain) and 0.15–0.18% (prostate). Conclusion: A rapid volumetric T1 mapping technique was developed. The technique enables high-resolution T1 mapping with adequate anatomical coverage in a clinically acceptable time. © 2021 Elsevier Inc.Note
12 month embargo; first published online 22 March 2021ISSN
0730-725XEISSN
1873-5894PubMed ID
33722634Version
Final accepted manuscriptae974a485f413a2113503eed53cd6c53
10.1016/j.mri.2021.03.003
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