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dc.contributor.authorLi, Zhitao
dc.contributor.authorFu, Zhiyang
dc.contributor.authorKeerthivasan, Mahesh
dc.contributor.authorBilgin, Ali
dc.contributor.authorJohnson, Kevin
dc.contributor.authorGalons, Jean-Philippe
dc.contributor.authorVedantham, Srinivasan
dc.contributor.authorMartin, Diego R
dc.contributor.authorAltbach, Maria I
dc.date.accessioned2021-04-08T02:16:21Z
dc.date.available2021-04-08T02:16:21Z
dc.date.issued2021-03-03
dc.identifier.citationLi, Z., Fu, Z., Keerthivasan, M., Bilgin, A., Johnson, K., Galons, J. P., ... & Altbach, M. I. (2021). Rapid high-resolution volumetric T1 mapping using a highly accelerated stack-of-stars Look Locker technique. Magnetic Resonance Imaging.en_US
dc.identifier.issn0730-725X
dc.identifier.pmid33722634
dc.identifier.doi10.1016/j.mri.2021.03.003
dc.identifier.urihttp://hdl.handle.net/10150/657648
dc.description.abstractPurpose: To develop a fast volumetric T1 mapping technique. Materials and methods: A stack-of-stars (SOS) Look Locker technique based on the acquisition of undersampled radial data (>30× relative to Nyquist) and an efficient multi-slab excitation scheme is presented. A principal-component based reconstruction is used to reconstruct T1 maps. Computer simulations were performed to determine the best choice of partitions per slab and degree of undersampling. The technique was validated in phantoms against reference T1 values measured with a 2D Cartesian inversion-recovery spin-echo technique. The SOS Look Locker technique was tested in brain (n = 4) and prostate (n = 5). Brain T1 mapping was carried out with and without kz acceleration and results between the two approaches were compared. Prostate T1 mapping was compared to standard techniques. A reproducibility study was conducted in brain and prostate. Statistical analyses were performed using linear regression and Bland Altman analysis. Results: Phantom T1 values showed excellent correlations between SOS Look Locker and the inversion-recovery spin-echo reference (r2 = 0.9965; p < 0.0001) and between SOS Look Locker with slab-selective and non-slab selective inversion pulses (r2 = 0.9999; p < 0.0001). In vivo results showed that full brain T1 mapping (1 mm3) with kz acceleration is achieved in 4 min 21 s. Full prostate T1 mapping (0.9 × 0.9 × 4 mm3) is achieved in 2 min 43 s. T1 values for brain and prostate were in agreement with literature values. A reproducibility study showed coefficients of variation in the range of 0.18–0.2% (brain) and 0.15–0.18% (prostate). Conclusion: A rapid volumetric T1 mapping technique was developed. The technique enables high-resolution T1 mapping with adequate anatomical coverage in a clinically acceptable time. © 2021 Elsevier Inc.en_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.rightsCopyright © 2021 Elsevier Inc. All rights reserved.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.subject3D radial MRIen_US
dc.subjectLook-Locker methoden_US
dc.subjectModel-baseden_US
dc.subjectT(1)en_US
dc.subjectT(1) mappingen_US
dc.titleRapid high-resolution volumetric T mapping using a highly accelerated stack-of-stars Look Locker techniqueen_US
dc.typeArticleen_US
dc.identifier.eissn1873-5894
dc.contributor.departmentDepartment of Electrical and Computer Engineering, the University of Arizonaen_US
dc.contributor.departmentDepartment of Medical Imaging, the University of Arizonaen_US
dc.contributor.departmentDepartment of Biomedical Engineering, the University of Arizonaen_US
dc.identifier.journalMagnetic Resonance Imagingen_US
dc.description.note12 month embargo; first published online 22 March 2021en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleMagnetic resonance imaging
dc.source.volume79
dc.source.beginpage28
dc.source.endpage37
dc.source.countryUnited States
dc.source.countryNetherlands


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