Pulmonary infection secondary to Blastobotrys raffinosifermentans in a cystic fibrosis patient: Review of the literature
AffiliationUniversity of Arizona
MetadataShow full item record
CitationAl‐Obaidi, M., Badali, H., Cañete‐Gibas, C., Patterson, H. P., & Wiederhold, N. P. (2021). Pulmonary infection secondary to Blastobotrys raffinosifermentans in a cystic fibrosis patient: Review of the literature. Mycoses.
Rights© 2021 Wiley-VCH GmbH.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractBackground: The genus Blastobotrys consists of at least 20 species. Disease in humans has been reported with B adeninivorans, B raffinosifermentans, B proliferans and B serpentis, mostly in immunocompromised patients and those with cystic fibrosis. Objective: We report a lung infection secondary to B raffinosifermentans in a cystic fibrosis patient successfully treated with isavuconazole and review the literature of invasive infections caused this genus. We also evaluated clinical isolates in our laboratory for species identification and antifungal susceptibility. Methods: Phylogenetic analysis was performed on a collection of 22 Blastobotrys isolates in our reference laboratory, and antifungal susceptibility patterns were determined for nine clinically available antifungals against 19 of these isolates. Results: By phylogenetic analysis, 21 of the 22 isolates in our collection were identified as B raffinosifermentans and only 1 as B adeninivorans. Most were cultured from the respiratory tract, although others were recovered from other sources, including CSF and blood. Isavuconazole, caspofungin and micafungin demonstrated the most potent in vitro activity, followed by amphotericin B. In contrast, fluconazole demonstrated poor activity. The patient in this case responded to isavuconazole treatment for breakthrough infection due to B raffinosifermentans that was cultured from pleural fluid while on posaconazole prophylaxis post–bilateral lung transplantation for cystic fibrosis. Conclusions: Blastobotrys species are rare causes of infections in humans and primarily occur in immunocompromised hosts. In our collection, the majority of isolates were identified as B raffinosifermentans. To our knowledge, this is the first report of successful treatment of such an infection with isavuconazole. © 2021 Wiley-VCH GmbH
Note12 month embargo; first published online 8 February 2021
VersionFinal accepted manuscript
- Invasive mycosis due to species of Blastobotrys in immunocompromised patients with reduced susceptibility to antifungals.
- Authors: Kumar A, Babu R, Bijulal S, Abraham M, Sasidharan P, Kathuria S, Sharma C, Meis JF, Chowdhary A
- Issue date: 2014 Nov
- Antifungal efficacy of isavuconazole and liposomal amphotericin B in a rabbit model of Exserohilum rostratum meningoencephalitis: A preclinical paradigm for management of CNS phaeohyphomycosis.
- Authors: Petraitis V, Petraitiene R, Katragkou A, Maung BBW, Moradi PW, Sussman-Straus GE, Naing E, Kovanda LL, Finkelman MA, Walsh TJ
- Issue date: 2021 Feb 4
- Evaluation of the Gradient Concentration Strip Method for Antifungal Susceptibility Testing of Isavuconazole and Comparators for <i>Mucorales</i> Species.
- Authors: Vidal P, Schwarz P, Dannaoui E
- Issue date: 2019 Oct
- Use of isavuconazole in a patient with voriconazole-induced QTc prolongation.
- Authors: Trang TP, Hanretty AM, Langelier C, Yang K
- Issue date: 2017 Aug
- Breaking the Mold: A Review of Mucormycosis and Current Pharmacological Treatment Options.
- Authors: Riley TT, Muzny CA, Swiatlo E, Legendre DP
- Issue date: 2016 Sep