• Login
    View Item 
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Pulmonary infection secondary to Blastobotrys raffinosifermentans in a cystic fibrosis patient: Review of the literature

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    myc.13252.pdf
    Size:
    18.18Mb
    Format:
    PDF
    Description:
    Final Accepted Manuscript
    Download
    Author
    Al-Obaidi, Mohanad
    Badali, Hamid
    Cañete-Gibas, Connie
    Patterson, Hoja P
    Wiederhold, Nathan P
    Affiliation
    University of Arizona
    Issue Date
    2021-02-08
    Keywords
    antifungal susceptibility
    Blastobotrys raffinosifermentans
    Blastobotrys species
    cystic fibrosis
    
    Metadata
    Show full item record
    Publisher
    Wiley Blackwell
    Citation
    Al‐Obaidi, M., Badali, H., Cañete‐Gibas, C., Patterson, H. P., & Wiederhold, N. P. (2021). Pulmonary infection secondary to Blastobotrys raffinosifermentans in a cystic fibrosis patient: Review of the literature. Mycoses.
    Journal
    Mycoses
    Rights
    © 2021 Wiley-VCH GmbH.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Background: The genus Blastobotrys consists of at least 20 species. Disease in humans has been reported with B adeninivorans, B raffinosifermentans, B proliferans and B serpentis, mostly in immunocompromised patients and those with cystic fibrosis. Objective: We report a lung infection secondary to B raffinosifermentans in a cystic fibrosis patient successfully treated with isavuconazole and review the literature of invasive infections caused this genus. We also evaluated clinical isolates in our laboratory for species identification and antifungal susceptibility. Methods: Phylogenetic analysis was performed on a collection of 22 Blastobotrys isolates in our reference laboratory, and antifungal susceptibility patterns were determined for nine clinically available antifungals against 19 of these isolates. Results: By phylogenetic analysis, 21 of the 22 isolates in our collection were identified as B raffinosifermentans and only 1 as B adeninivorans. Most were cultured from the respiratory tract, although others were recovered from other sources, including CSF and blood. Isavuconazole, caspofungin and micafungin demonstrated the most potent in vitro activity, followed by amphotericin B. In contrast, fluconazole demonstrated poor activity. The patient in this case responded to isavuconazole treatment for breakthrough infection due to B raffinosifermentans that was cultured from pleural fluid while on posaconazole prophylaxis post–bilateral lung transplantation for cystic fibrosis. Conclusions: Blastobotrys species are rare causes of infections in humans and primarily occur in immunocompromised hosts. In our collection, the majority of isolates were identified as B raffinosifermentans. To our knowledge, this is the first report of successful treatment of such an infection with isavuconazole. © 2021 Wiley-VCH GmbH
    Note
    12 month embargo; first published online 8 February 2021
    ISSN
    0933-7407
    EISSN
    1439-0507
    PubMed ID
    33555073
    DOI
    10.1111/myc.13252
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1111/myc.13252
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

    Related articles

    • Invasive mycosis due to species of Blastobotrys in immunocompromised patients with reduced susceptibility to antifungals.
    • Authors: Kumar A, Babu R, Bijulal S, Abraham M, Sasidharan P, Kathuria S, Sharma C, Meis JF, Chowdhary A
    • Issue date: 2014 Nov
    • Antifungal efficacy of isavuconazole and liposomal amphotericin B in a rabbit model of Exserohilum rostratum meningoencephalitis: A preclinical paradigm for management of CNS phaeohyphomycosis.
    • Authors: Petraitis V, Petraitiene R, Katragkou A, Maung BBW, Moradi PW, Sussman-Straus GE, Naing E, Kovanda LL, Finkelman MA, Walsh TJ
    • Issue date: 2021 Feb 4
    • Evaluation of the Gradient Concentration Strip Method for Antifungal Susceptibility Testing of Isavuconazole and Comparators for <i>Mucorales</i> Species.
    • Authors: Vidal P, Schwarz P, Dannaoui E
    • Issue date: 2019 Oct
    • Use of isavuconazole in a patient with voriconazole-induced QTc prolongation.
    • Authors: Trang TP, Hanretty AM, Langelier C, Yang K
    • Issue date: 2017 Aug
    • Breaking the Mold: A Review of Mucormycosis and Current Pharmacological Treatment Options.
    • Authors: Riley TT, Muzny CA, Swiatlo E, Legendre DP
    • Issue date: 2016 Sep
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.