A Risk Assessment for 1,4-dioxane in Cosmetics and Drinking Water
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
EmbargoRelease after 12/30/2023
Abstract1,4-Dioxane is a potential carcinogen that is a contaminant of drinking water and cosmetics. The present study addressed route-specific and aggregate exposure from drinking water and cosmetics. Exposure rates were generated by modeling both exposure pathways in ConsExpo Web Version 1.0.7, 31-03-2020.The generation of exposure rates allowed for the examination of 1,4-dioxane exposure in individual cosmetic products, drinking water, total cosmetic exposure, and aggregate exposure. Water had the highest exposure rates with values ranging from 1.006 x 10 -5 – 3.781 x 10-4 mg/kg-day. Cosmetic exposure rates ranged from 1.30 x 10-10 – 2.239 x 10-4 mg/kg-day. Cosmetic categories with harsh ingredients that require ethoxylation had the highest exposure rates. Route-specific cosmetic and drinking water exposure were not of concern at all exposure percentiles. Aggregated exposure started to become of concern at the 99th percentile of exposure with an aggregate risk index (ARI) of 1.85.
Degree ProgramGraduate College
Environmental Health Sciences