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dc.contributor.authorOrtiz, Alexander V
dc.contributor.authorAziz, David
dc.contributor.authorHestrin, Shaul
dc.date.accessioned2021-04-23T00:42:02Z
dc.date.available2021-04-23T00:42:02Z
dc.date.issued2020-10-20
dc.identifier.citationOrtiz, A. V., Aziz, D., & Hestrin, S. (2020). Motivation and Engagement during Visually Guided Behavior. Cell reports, 33(3), 108272.en_US
dc.identifier.issn2211-1247
dc.identifier.pmid33086072
dc.identifier.doi10.1016/j.celrep.2020.108272
dc.identifier.urihttp://hdl.handle.net/10150/657885
dc.description.abstractAnimal behavior is motivated by internal drives, such as thirst and hunger, generated in hypothalamic neurons that project widely to many brain areas. We find that water-restricted mice maintain stable, high-level contrast sensitivity and brief reaction time while performing a visual task, but then abruptly stop and become disengaged. Mice consume a significant amount of water when freely provided in their home cage immediately after the task, indicating that disengagement does not reflect cessation of thirst. Neuronal responses of V1 neurons are reduced in the disengaged state, but pupil diameter does not decrease, suggesting that animals' reduced level of arousal does not drive the transition to disengagement. Our findings indicate that satiation level alone does not have an instructive role in visually guided behavior and suggest that animals' behavior is governed by cost-benefit analysis that can override thirst signals.en_US
dc.language.isoenen_US
dc.publisherCELL PRESSen_US
dc.rights© 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.titleMotivation and Engagement during Visually Guided Behavioren_US
dc.typeArticleen_US
dc.identifier.eissn2211-1247
dc.contributor.departmentUniv Arizona, Coll Opt Scien_US
dc.identifier.journalCELL REPORTSen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleCell reports
dc.source.volume33
dc.source.issue3
dc.source.beginpage108272
dc.source.endpage
refterms.dateFOA2021-04-23T00:42:04Z
dc.source.countryUnited States
dc.source.countryUnited States


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© 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Except where otherwise noted, this item's license is described as © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).