Inflammatory response in human alveolar epithelial cells after TiO NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function
Medina-Ramírez, I E
Cassee, F R
De Vizcaya-Ruiz, A
AffiliationDepartament of Otolaryngology – Head & Neck Surgery, College of Medicine, University of Arizona
MetadataShow full item record
CitationJiménez-Chávez, A., Solorio-Rodríguez, A., Escamilla-Rivera, V., Leseman, D., Morales-Rubio, R., Uribe-Ramírez, M., ... & De Vizcaya-Ruiz, A. (2021). Inflammatory response in human alveolar epithelial cells after TiO2 NPs or ZnO NPs exposure: inhibition of surfactant protein A expression as an indicator for loss of lung function. Environmental Toxicology and Pharmacology, 103654.
RightsCopyright © 2021 Elsevier B.V. All rights reserved.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractThe increasing use of metal oxide nanoparticles (MONPs) as TiO2 NPs or ZnO NPs has led to environmental release and human exposure. The respiratory system, effects on lamellar bodies and surfactant protein A (SP-A) of pneumocytes, can be importantly affected. Exposure of human alveolar epithelial cells (A549) induced differential responses; a higher persistence of TiO2 in cell surface and uptake (measured by Atomic Force Microscopy) and sustained inflammatory response (by means of TNF-α, IL-10, and IL-6 release) and ROS generation were observed, whereas ZnO showed a modest response and low numbers in cell surface. A reduction in SP-A levels at 24 h of exposure to TiO2 NPs (concentration-dependent) or ZnO NPs (the higher concentration) was also observed, reversed by blocking the inflammatory response (by the inhibition of IL-6). Loss of SP-A represents a relevant target of MONPs-induced inflammatory response that could contribute to cellular damage and loss of lung function.
Note12 month embargo; available online 3 April 2021
VersionFinal accepted manuscript
- The effects of endoplasmic reticulum stress inducer thapsigargin on the toxicity of ZnO or TiO<sub>2</sub> nanoparticles to human endothelial cells.
- Authors: Gu Y, Cheng S, Chen G, Shen Y, Li X, Jiang Q, Li J, Cao Y
- Issue date: 2017 Mar
- Long-term exposure of A549 cells to titanium dioxide nanoparticles induces DNA damage and sensitizes cells towards genotoxic agents.
- Authors: Armand L, Tarantini A, Beal D, Biola-Clier M, Bobyk L, Sorieul S, Pernet-Gallay K, Marie-Desvergne C, Lynch I, Herlin-Boime N, Carriere M
- Issue date: 2016 Sep
- Epithelial to Mesenchymal transition, eIF2α phosphorylation and Hsp70 expression enable greater tolerance in A549 cells to TiO<sub>2</sub> over ZnO nanoparticles.
- Authors: Martin A, Sarkar A
- Issue date: 2019 Jan 24
- Evaluation of cytotoxic, genotoxic and inflammatory response in human alveolar and bronchial epithelial cells exposed to titanium dioxide nanoparticles.
- Authors: Ursini CL, Cavallo D, Fresegna AM, Ciervo A, Maiello R, Tassone P, Buresti G, Casciardi S, Iavicoli S
- Issue date: 2014 Nov
- Toxicological aspects of long-term treatment of keratinocytes with ZnO and TiO2 nanoparticles.
- Authors: Kocbek P, Teskac K, Kreft ME, Kristl J
- Issue date: 2010 Sep 6