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    Inflammatory response in human alveolar epithelial cells after TiO NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function

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    Thumbnail
    Name:
    ETAP-D-20-00992_R3.pdf
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    3.448Mb
    Format:
    PDF
    Description:
    Final Accepted Manuscript
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    Author
    Jiménez-Chávez, A
    Solorio-Rodríguez, A
    Escamilla-Rivera, V
    Leseman, D
    Morales-Rubio, R
    Uribe-Ramírez, M
    Campos-Villegas, L
    Medina-Ramírez, I E
    Arreola-Mendoza, L
    Cassee, F R
    De Vizcaya-Ruiz, A
    Show allShow less
    Affiliation
    Departament of Otolaryngology – Head & Neck Surgery, College of Medicine, University of Arizona
    Issue Date
    2021-04-03
    Keywords
    Interleukin 6
    MONPs biopersistence
    Surfactant protein A
    TiO(2) NPs
    ZnO NPs
    
    Metadata
    Show full item record
    Publisher
    Elsevier B.V.
    Citation
    Jiménez-Chávez, A., Solorio-Rodríguez, A., Escamilla-Rivera, V., Leseman, D., Morales-Rubio, R., Uribe-Ramírez, M., ... & De Vizcaya-Ruiz, A. (2021). Inflammatory response in human alveolar epithelial cells after TiO2 NPs or ZnO NPs exposure: inhibition of surfactant protein A expression as an indicator for loss of lung function. Environmental Toxicology and Pharmacology, 103654.
    Journal
    Environmental toxicology and pharmacology
    Rights
    Copyright © 2021 Elsevier B.V. All rights reserved.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The increasing use of metal oxide nanoparticles (MONPs) as TiO2 NPs or ZnO NPs has led to environmental release and human exposure. The respiratory system, effects on lamellar bodies and surfactant protein A (SP-A) of pneumocytes, can be importantly affected. Exposure of human alveolar epithelial cells (A549) induced differential responses; a higher persistence of TiO2 in cell surface and uptake (measured by Atomic Force Microscopy) and sustained inflammatory response (by means of TNF-α, IL-10, and IL-6 release) and ROS generation were observed, whereas ZnO showed a modest response and low numbers in cell surface. A reduction in SP-A levels at 24 h of exposure to TiO2 NPs (concentration-dependent) or ZnO NPs (the higher concentration) was also observed, reversed by blocking the inflammatory response (by the inhibition of IL-6). Loss of SP-A represents a relevant target of MONPs-induced inflammatory response that could contribute to cellular damage and loss of lung function.
    Note
    12 month embargo; available online 3 April 2021
    EISSN
    1872-7077
    PubMed ID
    33823299
    DOI
    10.1016/j.etap.2021.103654
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.etap.2021.103654
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

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