Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function
Bugda Gwilt, Katlynn
Miranti, Cynthia K
Lawlor, Michael W
AffiliationUniv Arizona, Dept Cellular & Mol Med, Coll Med
MetadataShow full item record
CitationHall, A., Fontelonga, T., Wright, A., Gwilt, K. B., Widrick, J., Pasut, A., ... & Gussoni, E. (2020). Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function. Skeletal muscle, 10(1), 1-16.
Rights© The Author(s). 2020 Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractExpression of CD82 is important to sustain satellite cell activation, as in its absence there is decreased cell proliferation and less efficient repair of injured muscle. Loss of CD82 in dystrophic muscle leads to a worsened phenotype compared to control dystrophic mice, with decreased pulmonary function, myofiber size, and muscle strength. Mechanistically, decreased myofiber size in CD82-/- dystrophic mice is not due to altered PTEN/AKT signaling, although increased phosphorylation of mTOR at Ser2448 was observed.
NoteOpen access journal
VersionFinal published version
Except where otherwise noted, this item's license is described as © The Author(s). 2020 Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
- CD82 Is a Marker for Prospective Isolation of Human Muscle Satellite Cells and Is Linked to Muscular Dystrophies.
- Authors: Alexander MS, Rozkalne A, Colletta A, Spinazzola JM, Johnson S, Rahimov F, Meng H, Lawlor MW, Estrella E, Kunkel LM, Gussoni E
- Issue date: 2016 Dec 1
- MyD88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice.
- Authors: Gallot YS, Straughn AR, Bohnert KR, Xiong G, Hindi SM, Kumar A
- Issue date: 2018 Oct 1
- Alterations in Notch signalling in skeletal muscles from mdx and dko dystrophic mice and patients with Duchenne muscular dystrophy.
- Authors: Church JE, Trieu J, Chee A, Naim T, Gehrig SM, Lamon S, Angelini C, Russell AP, Lynch GS
- Issue date: 2014 Apr
- Decrease of myofiber branching via muscle-specific expression of the olfactory receptor mOR23 in dystrophic muscle leads to protection against mechanical stress.
- Authors: Pichavant C, Burkholder TJ, Pavlath GK
- Issue date: 2016
- KAI1/CD82 decreases Rac1 expression and cell proliferation through PI3K/Akt/mTOR pathway in H1299 lung carcinoma cells.
- Authors: Choi UJ, Jee BK, Lim Y, Lee KH
- Issue date: 2009 Jan