Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function
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Univ Arizona, Dept Cellular & Mol Med, Coll MedIssue Date
2020-11-27Metadata
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Hall, A., Fontelonga, T., Wright, A., Gwilt, K. B., Widrick, J., Pasut, A., ... & Gussoni, E. (2020). Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function. Skeletal muscle, 10(1), 1-16.Journal
SKELETAL MUSCLERights
© The Author(s). 2020 Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Expression of CD82 is important to sustain satellite cell activation, as in its absence there is decreased cell proliferation and less efficient repair of injured muscle. Loss of CD82 in dystrophic muscle leads to a worsened phenotype compared to control dystrophic mice, with decreased pulmonary function, myofiber size, and muscle strength. Mechanistically, decreased myofiber size in CD82-/- dystrophic mice is not due to altered PTEN/AKT signaling, although increased phosphorylation of mTOR at Ser2448 was observed.Note
Open access journalISSN
2044-5040EISSN
2044-5040PubMed ID
33243288Version
Final published versionScopus Count
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Except where otherwise noted, this item's license is described as © The Author(s). 2020 Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.