Interaction of Age and Self-reported Physical Sports Activity on White Matter Hyperintensity Volume in Healthy Older Adults
AuthorFranchetti, Mary Kathryn
Bharadwaj, Pradyumna K
Nguyen, Lauren A
Van Etten, Emily J
Klimentidis, Yann C
Hishaw, Georg A
Trouard, Theodore P
Raichlen, David A
Alexander, Gene E
AffiliationUniv Arizona, Dept Psychol
Univ Arizona, Dept Epidemiol & Biostat
Univ Arizona, Dept Neurol
Univ Arizona, Dept Biomed Engn
Univ Arizona, Dept Med Imaging
Univ Arizona, Neurosci Grad Interdisciplinary Program
Univ Arizona, Physiol Sci Grad Interdisciplinary Program
Univ Arizona, Dept Psychiat
Keywordsphysical activity (exercise)
moderate to vigorous physical activity (MVPA)
white matter (WM)
regional white matter lesion load
white matter hyperintensity volume
MetadataShow full item record
PublisherFRONTIERS MEDIA SA
CitationFranchetti, M. K., Bharadwaj, P. K., Nguyen, L. A., Van Etten, E. J., Klimentidis, Y. C., Hishaw, G. A., ... & Alexander, G. E. (2020). Interaction of Age and Self-reported Physical Sports Activity on White Matter Hyperintensity Volume in Healthy Older Adults. Frontiers in Aging Neuroscience, 12, 346.
JournalFRONTIERS IN AGING NEUROSCIENCE
RightsCopyright © 2020 Franchetti, Bharadwaj, Nguyen, Van Etten, Klimentidis, Hishaw, Trouard, Raichlen and Alexander. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractCerebral white matter (WM) lesion load, as measured by white matter hyperintensity (WMH) volume with magnetic resonance imaging (MRI), has been associated with increasing age and cardiovascular risk factors, like hypertension. Physical sports activity (PSA) may play an important role in maintaining WM in the context of healthy aging. In 196 healthy older adults, we investigated whether participants reporting high levels of PSA (n = 36) had reduced total and regional WMH volumes compared to those reporting low levels of PSA (n = 160). Age group [young-old (YO) = 50-69 years; old-old (OO) = 70-89 years], PSA group, and age by PSA group interaction effects were tested, with sex, hypertension, and body mass index (BMI) as covariates. We found significant main effects for age group and age by PSA group interactions for total, frontal, temporal, and parietal WMH volumes. There were no main effects of PSA group on WMH volumes. The OO group with low PSA had greater total, frontal, temporal, and parietal WMH volumes than the YO with low PSA and OO with high PSA groups. WMH volumes for the YO and OO groups with high PSA were comparable. These findings indicate an age group difference in those with low PSA, with greater WMH volumes in older adults, which was not observed in those with high PSA. The results suggest that engaging in high levels of PSA may be an important lifestyle factor that can help to diminish WMH lesion load in old age, potentially reducing the impact of brain aging.
NoteOpen access journal
VersionFinal published version
Except where otherwise noted, this item's license is described as Copyright © 2020 Franchetti, Bharadwaj, Nguyen, Van Etten, Klimentidis, Hishaw, Trouard, Raichlen and Alexander. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
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