Contributions of Hippocampal Volume to Cognition in Healthy Older Adults
Kraft, Jessica N
Evangelista, Nicole D
Hausman, Hanna K
Boutzoukas, Emanuel M
Van Etten, Emily J
Bharadwaj, Pradyumna K
Smith, Samantha G
Porges, Eric C
Hishaw, Georg A
Wu, Samuel S
Alexander, Gene E
Woods, Adam J
AffiliationUniv Arizona, Evelyn F McKnight Brain Inst
Univ Arizona, Coll Sci, Dept Psychol, Sch Mind Brain & Behav
Univ Arizona, Dept Neurol
Univ Arizona, Dept Psychiat
Univ Arizona, Neurosci Grad Interdisciplinary Program
Univ Arizona, Physiol Sci Grad Interdisciplinary Program
MetadataShow full item record
PublisherFRONTIERS MEDIA SA
CitationHardcastle, C., O’Shea, A., Kraft, J. N., Albizu, A., Evangelista, N. D., Hausman, H. K., ... & Woods, A. J. (2020). Contributions of Hippocampal Volume to Cognition in Healthy Older Adults. Frontiers in Aging Neuroscience, 12, 365.
JournalFRONTIERS IN AGING NEUROSCIENCE
RightsCopyright © 2020 Hardcastle, O’Shea, Kraft, Albizu, Evangelista, Hausman, Boutzoukas, Van Etten, Bharadwaj, Song, Smith, Porges, Dekosky, Hishaw, Wu, Marsiske, Cohen, Alexander and Woods. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use,distribution or reproduction is permitted which does not comply with these terms.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractObjective: The association between hippocampal volume and memory is continuing to be characterized in healthy older adults. Prior research suggests smaller hippocampal volume in healthy older adults is associated with poorer episodic memory and processing speed, as well as working memory, verbal learning, and executive functioning as measured by the NIH Toolbox Fluid (Fluid Cognition Composite, FCC) and Crystalized Cognition Composites (CCC). This study aimed to replicate these findings and to evaluate the association between: (1) hippocampal asymmetry index and cognition; and (2) independent contributions of the left and right hippocampal volume and cognition in a large sample of healthy older adults. Participants and Methods: One-hundred and eighty-three healthy older adults (M age = 71.72, SD = 5.3) received a T1-weighted sequence on a 3T scanner. Hippocampal subfields were extracted using FreeSurfer 6.0 and combined to provide left, right, and total hippocampal volumes. FCC subtests include Dimensional Change Card Sort, Flanker Inhibitory Control and Attention, List Sorting, Picture Sequence Memory, and Pattern Comparison. CCC subtests include Picture Vocabulary and Oral Reading Recognition. Multiple linear regressions were performed predicting cognition composites from the total, left and right, and asymmetry of hippocampal volume, controlling for sex, education, scanner, and total intracranial volume. Multiple comparisons in primary analyses were corrected using a false discovery rate (FDR) of p < 0.05. Results: FCC scores were positively associated with total (β = 0.226, FDR q = 0.044) and left (β = 0.257, FDR q = 0.024) hippocampal volume. Within FCC, Picture Sequence Memory scores positively associated with total (β = 0.284, p = 0.001) and left (β = 0.98, p = 0.001) hippocampal volume. List Sorting scores were also positively associated with left hippocampal volume (β = 0.189, p = 0.029). Conclusions: These results confirm previous research suggesting that bilateral hippocampal volume is associated with FCC, namely episodic memory. The present study also suggests the left hippocampal volume may be more broadly associated with both episodic and working memory. Studies should continue to investigate lateralized hippocampal contributions to aging processes to better identify predictors of cognitive decline.
NoteOpen access journal
VersionFinal published version
- Assessment of Neighborhood Poverty, Cognitive Function, and Prefrontal and Hippocampal Volumes in Children.
- Authors: Taylor RL, Cooper SR, Jackson JJ, Barch DM
- Issue date: 2020 Nov 2
- The relation of hippocampal subfield volumes to verbal episodic memory measured by the California Verbal Learning Test II in healthy adults.
- Authors: Aslaksen PM, Bystad MK, Ørbo MC, Vangberg TR
- Issue date: 2018 Oct 1
- Roles of hippocampal subfields in verbal and visual episodic memory.
- Authors: Zammit AR, Ezzati A, Zimmerman ME, Lipton RB, Lipton ML, Katz MJ
- Issue date: 2017 Jan 15
- Differential association of left and right hippocampal volumes with verbal episodic and spatial memory in older adults.
- Authors: Ezzati A, Katz MJ, Zammit AR, Lipton ML, Zimmerman ME, Sliwinski MJ, Lipton RB
- Issue date: 2016 Dec
- Cognitive Aging and the Hippocampus in Older Adults.
- Authors: O'Shea A, Cohen RA, Porges EC, Nissim NR, Woods AJ
- Issue date: 2016