Show simple item record

dc.contributor.authorHardcastle, Cheshire
dc.contributor.authorO'Shea, Andrew
dc.contributor.authorKraft, Jessica N
dc.contributor.authorAlbizu, Alejandro
dc.contributor.authorEvangelista, Nicole D
dc.contributor.authorHausman, Hanna K
dc.contributor.authorBoutzoukas, Emanuel M
dc.contributor.authorVan Etten, Emily J
dc.contributor.authorBharadwaj, Pradyumna K
dc.contributor.authorSong, Hyun
dc.contributor.authorSmith, Samantha G
dc.contributor.authorPorges, Eric C
dc.contributor.authorDeKosky, Steven
dc.contributor.authorHishaw, Georg A
dc.contributor.authorWu, Samuel S
dc.contributor.authorMarsiske, Michael
dc.contributor.authorCohen, Ronald
dc.contributor.authorAlexander, Gene E
dc.contributor.authorWoods, Adam J
dc.date.accessioned2021-05-04T21:41:41Z
dc.date.available2021-05-04T21:41:41Z
dc.date.issued2020-11-05
dc.identifier.citationHardcastle, C., O’Shea, A., Kraft, J. N., Albizu, A., Evangelista, N. D., Hausman, H. K., ... & Woods, A. J. (2020). Contributions of Hippocampal Volume to Cognition in Healthy Older Adults. Frontiers in Aging Neuroscience, 12, 365.en_US
dc.identifier.issn1663-4365
dc.identifier.pmid33250765
dc.identifier.doi10.3389/fnagi.2020.593833
dc.identifier.urihttp://hdl.handle.net/10150/658135
dc.description.abstractObjective: The association between hippocampal volume and memory is continuing to be characterized in healthy older adults. Prior research suggests smaller hippocampal volume in healthy older adults is associated with poorer episodic memory and processing speed, as well as working memory, verbal learning, and executive functioning as measured by the NIH Toolbox Fluid (Fluid Cognition Composite, FCC) and Crystalized Cognition Composites (CCC). This study aimed to replicate these findings and to evaluate the association between: (1) hippocampal asymmetry index and cognition; and (2) independent contributions of the left and right hippocampal volume and cognition in a large sample of healthy older adults. Participants and Methods: One-hundred and eighty-three healthy older adults (M age = 71.72, SD = 5.3) received a T1-weighted sequence on a 3T scanner. Hippocampal subfields were extracted using FreeSurfer 6.0 and combined to provide left, right, and total hippocampal volumes. FCC subtests include Dimensional Change Card Sort, Flanker Inhibitory Control and Attention, List Sorting, Picture Sequence Memory, and Pattern Comparison. CCC subtests include Picture Vocabulary and Oral Reading Recognition. Multiple linear regressions were performed predicting cognition composites from the total, left and right, and asymmetry of hippocampal volume, controlling for sex, education, scanner, and total intracranial volume. Multiple comparisons in primary analyses were corrected using a false discovery rate (FDR) of p < 0.05. Results: FCC scores were positively associated with total (β = 0.226, FDR q = 0.044) and left (β = 0.257, FDR q = 0.024) hippocampal volume. Within FCC, Picture Sequence Memory scores positively associated with total (β = 0.284, p = 0.001) and left (β = 0.98, p = 0.001) hippocampal volume. List Sorting scores were also positively associated with left hippocampal volume (β = 0.189, p = 0.029). Conclusions: These results confirm previous research suggesting that bilateral hippocampal volume is associated with FCC, namely episodic memory. The present study also suggests the left hippocampal volume may be more broadly associated with both episodic and working memory. Studies should continue to investigate lateralized hippocampal contributions to aging processes to better identify predictors of cognitive decline.en_US
dc.language.isoenen_US
dc.publisherFRONTIERS MEDIA SAen_US
dc.rightsCopyright © 2020 Hardcastle, O’Shea, Kraft, Albizu, Evangelista, Hausman, Boutzoukas, Van Etten, Bharadwaj, Song, Smith, Porges, Dekosky, Hishaw, Wu, Marsiske, Cohen, Alexander and Woods. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectagingen_US
dc.subjectcognitionen_US
dc.subjecthippocampusen_US
dc.subjectmagnetic resonance imagingen_US
dc.subjectbrain volumeen_US
dc.subjectNIH toolboxen_US
dc.titleContributions of Hippocampal Volume to Cognition in Healthy Older Adultsen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Evelyn F McKnight Brain Insten_US
dc.contributor.departmentUniv Arizona, Coll Sci, Dept Psychol, Sch Mind Brain & Behaven_US
dc.contributor.departmentUniv Arizona, Dept Neurolen_US
dc.contributor.departmentUniv Arizona, Dept Psychiaten_US
dc.contributor.departmentUniv Arizona, Neurosci Grad Interdisciplinary Programen_US
dc.contributor.departmentUniv Arizona, Physiol Sci Grad Interdisciplinary Programen_US
dc.identifier.journalFRONTIERS IN AGING NEUROSCIENCEen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleFrontiers in aging neuroscience
dc.source.volume12
dc.source.beginpage593833
dc.source.endpage
refterms.dateFOA2021-05-04T21:41:43Z
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countrySwitzerland


Files in this item

Thumbnail
Name:
fnagi-12-593833.pdf
Size:
1.391Mb
Format:
PDF
Description:
Final Published Version

This item appears in the following Collection(s)

Show simple item record

Copyright © 2020 Hardcastle, O’Shea, Kraft, Albizu, Evangelista, Hausman, Boutzoukas, Van Etten, Bharadwaj, Song, Smith, Porges, Dekosky, Hishaw, Wu, Marsiske, Cohen, Alexander and Woods. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Except where otherwise noted, this item's license is described as Copyright © 2020 Hardcastle, O’Shea, Kraft, Albizu, Evangelista, Hausman, Boutzoukas, Van Etten, Bharadwaj, Song, Smith, Porges, Dekosky, Hishaw, Wu, Marsiske, Cohen, Alexander and Woods. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).