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dc.contributor.authorStatham, Sally
dc.date.accessioned2021-05-13T03:58:52Z
dc.date.available2021-05-13T03:58:52Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/10150/658286
dc.descriptionA Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.
dc.description.abstractThe aim of this case study was to assess vascular function in a 27-year-old male-to-female transgender endurance athlete before hormone therapy and during treatment with gender affirming hormone therapy (GAHT) in an effort to better understand the effects of estrogen therapy and testosterone blockade on male vascular physiology. Testing occurred at 4-8 week intervals for 19 months. At each visit, testing included measurement of blood hormone levels including free testosterone, total testosterone and estradiol, resting heart rate and blood pressure, non-invasive central blood pressure measurements, pulse wave velocity (PWV), ultrasound quantified arterial flow mediated dilation (FMD), and dual-energy x-ray absorptiometry (DEXA) scans. These data were analyzed over time to observe gross trends and then analyzed for correlation. Visceral body fat measured remained unchanged from baseline after 15 months gender affirming hormone therapy. Systolic and diastolic blood pressures increased throughout treatment and systolic pressures were positively correlated with time. PWV showed signs of decreasing arterial stiffness after initiation of GAHT, but returned to baseline by the end of the study. FMD trended downwards initially with GAHT, indicating reduced vascular reactivity, but returned towards baseline following sustained treatment with GAHT. More research is needed to examine the long-term effects of gender affirming hormone therapy on vascular function, blood pressure, and vascular stiffness.en_US
dc.language.isoen
dc.publisherThe University of Arizona.
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the College of Medicine - Phoenix, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectTransgenderen_US
dc.subjectCardiovascularen_US
dc.subjectHormone Replacement Therapyen_US
dc.titleA Case Study: The Effect of Hormone Therapy on Vascular Function in a Male-to-Female Transgender Endurance Athleteen_US
dc.typeThesis
dc.typePoster
dc.typetext
dc.contributor.departmentThe University of Arizona College of Medicine - Phoenix
dc.description.collectioninformationThis item is part of the College of Medicine - Phoenix Scholarly Projects 2021 collection. For more information, contact the Phoenix Biomedical Campus Library at pbc-library@email.arizona.edu.
dc.contributor.mentorAngadi, Siddhartha
refterms.dateFOA2021-05-13T03:58:53Z


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