Three arenaviruses in three subspecific natal multimammate mouse taxa in Tanzania: Same host specificity, but different spatial genetic structure?
Author
Cuypers, L.N.Baird, S.J.E.
Hánová, A.
Locus, T.
Katakweba, A.S.
Gryseels, S.
Bryja, J.
Leirs, H.
de, Bellocq, J.G.
Affiliation
Department of Ecology and Evolutionary Biology, University of ArizonaIssue Date
2020Keywords
Arenavirus host specificityGairo mammarenavirus
Luna mammarenavirus
Morogoro mammarenavirus
Regional prevalence differences
Spatial genetic structure
Metadata
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Oxford University PressCitation
Cuypers, L. N., Baird, S. J., Hánová, A., Locus, T., Katakweba, A. S., Gryseels, S., ... & Goüy de Bellocq, J. (2020). Three arenaviruses in three subspecific natal multimammate mouse taxa in Tanzania: same host specificity, but different spatial genetic structure?. Virus evolution, 6(2), veaa039.Journal
Virus EvolutionRights
Copyright © The Author(s) 2020. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/).Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Mastomys natalensis is widespread in sub-Saharan Africa and hosts several arenavirus species, including the pathogenic zoonotic Lassa virus in West Africa. Mitochondrial lineages sub-divide the range of M. natalensis and have been associated with cryptic structure within the species. To test specificity of arenaviruses to hosts carrying these lineages, we screened 1772 M. natalensis in a large area of Tanzania where three mitochondrial lineages meet. We detected fifty-two individuals that were positive for one of three arenaviruses: Gairo, Morogoro, and Luna virus. This is the first record of Luna virus in Tanzania. We confirmed the specificity of each arenavirus to a distinct host mitochondrial lineage except for three cases in one locality at the centre of a host hybrid zone. No arenaviruses were detected in a large part of the study area. Morogoro and Gairo virus showed differences in prevalence (Morogoro virus lower than Gairo virus) and in genetic structure (Morogoro virus more structured than Gairo virus). However, both viruses have genetic neighbourhood size estimates of the same order of magnitude as Lassa virus. While differences in arenavirus and/or host evolutionary and ecological dynamics may exist, Tanzanian arenaviruses could be suited to model Lassa virus dynamics in M. natalensis. VC The Author(s) 2020. Published by Oxford University Press.Note
Open access journalISSN
2057-1577Version
Final published versionae974a485f413a2113503eed53cd6c53
10.1093/ve/veaa039
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Except where otherwise noted, this item's license is described as Copyright © The Author(s) 2020. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/).