Interaction effect of the mediterranean diet and an obesity genetic risk score on adiposity and metabolic syndrome in adolescents: The HELENA study
Name:
nutrients-12-03841-v2.pdf
Size:
1.761Mb
Format:
PDF
Description:
Final Published Version
Author
Seral-Cortes, M.Sabroso-Lasa, S.
de Miguel-Etayo, P.
Gonzalez-Gross, M.
Gesteiro, E.
Molina-Hidalgo, C.
de Henauw, S.
Erhardt, É.
Censi, L.
Manios, Y.
Karaglani, E.
Widhalm, K.
Kafatos, A.
Beghin, L.
Meirhaeghe, A.
Salazar-Tortosa, D.
Ruiz, J.R.
Moreno, L.A.
Esteban, L.M.
Labayen, I.
Affiliation
Department of Ecology and Evolutionary Biology, University of ArizonaIssue Date
2020
Metadata
Show full item recordPublisher
MDPI AGCitation
Seral-Cortes, M., Sabroso-Lasa, S., Miguel-Etayo, D., Gonzalez-Gross, M., Gesteiro, E., Molina-Hidalgo, C., ... & Labayen, I. (2020). Interaction Effect of the Mediterranean Diet and an Obesity Genetic Risk Score on Adiposity and Metabolic Syndrome in Adolescents: The HELENA Study. Nutrients, 12(12), 3841.Journal
NutrientsRights
Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Obesity and metabolic syndrome (MetS) are worldwide major health challenges. The Mediterranean diet (MD) is associated with a better cardiometabolic profile, but these beneficial effects may be influenced by genetic variations, modulating the predisposition to obesity or MetS. The aim was to assess whether interaction effects occur between an obesity genetic risk score (obesity-GRS) and the MD on adiposity and MetS in European adolescents. Multiple linear regression models were used to assess the interaction effects of an obesity-GRS and the MD on adiposity and MetS and its components. Interaction effects between the MD on adiposity and MetS were observed in both sex groups (p < 0.05). However, those interaction effects were only expressed in a certain number of adolescents, when a limited number of risk alleles were present. Regarding adiposity, a total of 51.1% males and 98.7% females had lower body mass index (BMI) as a result of higher MD adherence. Concerning MetS, only 9.9% of males with higher MD adherence had lower MetS scores. However, the same effect was observed in 95.2% of females. In conclusion, obesity-related genotypes could modulate the relationship between MD adherence and adiposity and MetS in European adolescents; the interaction effect was higher in females than in males. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.Note
Open access journalISSN
2072-6643Version
Final published versionae974a485f413a2113503eed53cd6c53
10.3390/nu12123841
Scopus Count
Collections
Except where otherwise noted, this item's license is described as Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).