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Genomic Characterization of Campylobacter jejuni Adapted to the Guinea Pig (Cavia porcellus) Host

dc.contributor.authorParker, C.T.
dc.contributor.authorCooper, K.K.
dc.contributor.authorSchiaffino, F.
dc.contributor.authorMiller, W.G.
dc.contributor.authorHuynh, S.
dc.contributor.authorGray, H.K.
dc.contributor.authorOlortegui, M.P.
dc.contributor.authorBardales, P.G.
dc.contributor.authorTrigoso, D.R.
dc.contributor.authorPenataro-Yori, P.
dc.contributor.authorKosek, M.N.
dc.date.accessioned2021-06-17T01:09:17Z
dc.date.available2021-06-17T01:09:17Z
dc.date.issued2021
dc.identifier.citationParker, C. T., Cooper, K. K., Schiaffino, F., Miller, W. G., Huynh, S., Gray, H. K., ... & Kosek, M. N. (2021). Genomic Characterization of Campylobacter jejuni Adapted to the Guinea Pig (Cavia porcellus) Host. Frontiers in Cellular and Infection Microbiology, 11, 174.
dc.identifier.issn2235-2988
dc.identifier.doi10.3389/fcimb.2021.607747
dc.identifier.urihttp://hdl.handle.net/10150/659912
dc.description.abstractCampylobacter jejuni is the leading bacterial cause of gastroenteritis worldwide with excessive incidence in low-and middle-income countries (LMIC). During a survey for C. jejuni from putative animal hosts in a town in the Peruvian Amazon, we were able to isolate and whole genome sequence two C. jejuni strains from domesticated guinea pigs (Cavia porcellus). The C. jejuni isolated from guinea pigs had a novel multilocus sequence type that shared some alleles with other C. jejuni collected from guinea pigs. Average nucleotide identity and phylogenetic analysis with a collection of C. jejuni subsp. jejuni and C. jejuni subsp. doylei suggest that the guinea pig isolates are distinct. Genomic comparisons demonstrated gene gain and loss that could be associated with guinea pig host specialization related to guinea pig diet, anatomy, and physiology including the deletion of genes involved with selenium metabolism, including genes encoding the selenocysteine insertion machinery and selenocysteine-containing proteins. © Copyright © 2021 Parker, Cooper, Schiaffino, Miller, Huynh, Gray, Olortegui, Bardales, Trigoso, Penataro-Yori and Kosek.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.rightsCopyright © 2021 Parker, Cooper, Schiaffino, Miller, Huynh, Gray, Olortegui, Bardales, Trigoso, Penataro-Yori and Kosek. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCampylobacter jejuni
dc.subjectcampylobacteriosis
dc.subjectgastroenteritis
dc.subjectselenocysteine
dc.subjectsource attribution
dc.titleGenomic Characterization of Campylobacter jejuni Adapted to the Guinea Pig (Cavia porcellus) Host
dc.typeArticle
dc.typetext
dc.contributor.departmentSchool of Animal and Comparative Biomedical Sciences, University of Arizona
dc.identifier.journalFrontiers in Cellular and Infection Microbiology
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleFrontiers in Cellular and Infection Microbiology
refterms.dateFOA2021-06-17T01:09:17Z


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Copyright © 2021 Parker, Cooper, Schiaffino, Miller, Huynh, Gray, Olortegui, Bardales, Trigoso, Penataro-Yori and Kosek. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Except where otherwise noted, this item's license is described as Copyright © 2021 Parker, Cooper, Schiaffino, Miller, Huynh, Gray, Olortegui, Bardales, Trigoso, Penataro-Yori and Kosek. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).