Exposure to Blue Wavelength Light Is Associated With Increases in Bidirectional Amygdala-DLPFC Connectivity at Rest
AffiliationSocial, Cognitive, and Affective Neuroscience Laboratory, Department of Psychiatry, University of Arizona
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PublisherFrontiers Media S.A.
CitationAlkozei, A., Dailey, N. S., Bajaj, S., Vanuk, J. R., Raikes, A. C., & Killgore, W. D. (2021). Exposure to Blue Wavelength Light Is Associated With Increases in Bidirectional Amygdala-DLPFC Connectivity at Rest. Frontiers in neurology, 12, 401.
JournalFrontiers in Neurology
RightsCopyright © 2021 Alkozei, Dailey, Bajaj, Vanuk, Raikes and Killgore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractBlue wavelength light has been used successfully as a treatment method for certain mood disorders, but, the underlying mechanisms behind the mood enhancing effects of light remain poorly understood. We investigated the effects of a single dose of 30 min of blue wavelength light (n = 17) vs. amber wavelength light (n = 12) exposure in a sample of healthy adults on subsequent resting-state functional and directed connectivity, and associations with changes in state affect. Individuals who received blue vs. amber wavelength light showed greater positive connectivity between the right amygdala and a region within the left dorsolateral prefrontal cortex (DLPFC). In addition, using granger causality, the findings showed that individuals who received blue wavelength light displayed greater bidirectional information flow between these two regions relative to amber light. Furthermore, the strength of amygdala-DLPFC functional connectivity was associated with greater decreases in negative mood for the blue, but not the amber light condition. Blue light exposure may positively influence mood by modulating greater information flow between the amygdala and the DLPFC, which may result in greater engagement of cognitive control strategies that are needed to perceive and regulate arousal and mood. © Copyright © 2021 Alkozei, Dailey, Bajaj, Vanuk, Raikes and Killgore.
NoteOpen access journal
VersionFinal published version
Except where otherwise noted, this item's license is described as Copyright © 2021 Alkozei, Dailey, Bajaj, Vanuk, Raikes and Killgore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).