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    The Interaction of Osmotic and Heavy Metal Stress in C. elegans

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    Author
    Turner, Emily Anne
    Issue Date
    2021
    Keywords
    C. elegans
    Heavy metal
    Osmotic
    Stress
    Advisor
    Sutphin, George L.
    
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    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Most cells encounter some form of cellular stress (e.g., hypoxia, unfolded proteins, oxidative stress) during their life cycle. To combat such stresses, cells activate a variety of response pathways that can ameliorate the effects of the stress. Relatively little is understood about how these pathways interact when cells are challenged with multiple stresses simultaneously. Our goal is to understand how multiple forms of concurrent stress can alter cellular response pathways, and the subsequent impact on health and survival. We examined the combination of heavy metal and osmotic stress, induced by cadmium chloride and sodium chloride, respectively, in C. elegans. We found that lifespan is decreased by the combined stress to a greater extent than either individual stress and identified a potential mechanism for this increased toxicity. Cadmium disrupts the osmotic stress response by interfering with the production of glycerol, an osmolyte that is typically upregulated as a core part of the osmotic stress response in C. elegans. In addition, we have evidence supporting both antagonistic and synergistic models of interaction between cadmium and sodium stress. Based on our work and the literature surrounding cadmium and sodium stress response, we have identified multiple points at which the two response pathways may interact. In future work we will evaluate each mechanism and determine which are critical to the downstream consequences of the combined stress and associated stress response.
    Type
    text
    Electronic Thesis
    Degree Name
    M.S.
    Degree Level
    masters
    Degree Program
    Graduate College
    Molecular & Cellular Biology
    Degree Grantor
    University of Arizona
    Collections
    Master's Theses

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