We are upgrading the repository! A content freeze is in effect until November 22nd, 2024 - no new submissions will be accepted; however, all content already published will remain publicly available. Please reach out to repository@u.library.arizona.edu with your questions, or if you are a UA affiliate who needs to make content available soon. Note that any new user accounts created after September 22, 2024 will need to be recreated by the user in November after our migration is completed.
The GSDMB rs7216389 SNP is associated with chronic rhinosinusitis in a multi‐institutional cohort
Name:
GSDMB Rev 4-23 clean.pdf
Size:
332.9Kb
Format:
PDF
Description:
Final Accepted Manuscript
Author
Zack, Dana E.Stern, Debra A.
Willis, Amanda L.
Kim, Alexander S.
Mansfield, Corinne J.
Reed, Danielle R.
Brooks, Steven G.
Adappa, Nithin D.
Palmer, James N.
Cohen, Noam A.
Chiu, Alexander G.
Song, Brian H.
le Chris, H.
Chang, Eugene H.
Affiliation
Department of Otolaryngology, University of ArizonaAsthma and Airway Disease Research Center, University of Arizona
Issue Date
2021-06-02
Metadata
Show full item recordPublisher
WileyCitation
Zack, D. E., Stern, D. A., Willis, A. L., Kim, A. S., Mansfield, C. J., Reed, D. R., Brooks, S. G., Adappa, N. D., Palmer, J. N., Cohen, N. A., Chiu, A. G., Song, B. H., Le, C. H., & Chang, E. H. (2021). The GSDMB rs7216389 SNP is associated with chronic rhinosinusitis in a multi-institutional cohort. International Forum of Allergy and Rhinology.Rights
© 2021 ARS-AAOA, LLC.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Background: Chronic rhinosinusitis (CRS) is a multifactorial disease with a high co-occurrence with asthma. In this multicohort study, we tested whether single nucleotide polymorphisms (SNPs) associated with childhood asthma and rhinovirus (RV)-associated disease are related to an increased susceptibility to adult CRS in a multicohort retrospective case-control study. Methods: Participants at two tertiary academic rhinology centers, University of Arizona (UofA) and University of Pennsylvania (UPenn) were recruited. Cases were defined as those with physician diagnosed CRS (UofA, n = 149; UPenn, n = 250), and healthy controls were those without CRS (UofA, n = 66; UPenn, n = 275). Genomic DNA was screened for the GSDMB rs7216389 SNP and CDHR3 rs6967330 SNP. Gene dosage, or the number of combined risk alleles in a single subject was calculated. Meta-analysis of the association between GSDMB or CDHR3 genotypes and CRS was performed and additive gene dosage effect for each population calculated using p for trend. Results: A meta-analysis revealed a combined increased risk for CRS in subjects with the GSDMB rs7216389 SNP (odds ratio [OR] 1.40; 95% confidence interval [CI], 1.16–1.76; p = 0.004). Both the UofA (OR 1.73; 95% CI, 1.23–2.43; p = 0.002) and UPenn (OR 1.27; 95% CI, 1.02–1.58; p = 0.035) populations showed a significant positive association between the number of combined risk alleles of GSDMB rs7216389 SNP and CDHR3 rs6967330 SNP and risk for CRS. Conclusion: Carriers of the GSDMB rs7216389 SNP and CDHR3 rs6967330 SNP are at increased susceptibility for CRS. These data suggest that therapeutic approaches to target aberrant responses to RV infection may play a role in the treatment of unified airway disease. © 2021 ARS-AAOA, LLCNote
12 month embargo; first published: 02 June 2021ISSN
2042-6976EISSN
2042-6984Version
Final accepted manuscriptae974a485f413a2113503eed53cd6c53
10.1002/alr.22824