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dc.contributor.authorSinjab, M.M.
dc.contributor.authorRubinfeld, R.S.
dc.contributor.authorWagner, K.
dc.contributor.authorParsons, Jnr, E.C.
dc.contributor.authorCummings, A.B.
dc.contributor.authorBelin, M.W.
dc.date.accessioned2021-07-16T01:28:08Z
dc.date.available2021-07-16T01:28:08Z
dc.date.issued2021
dc.identifier.citationSinjab, M. M., Rubinfeld, R. S., Wagner, K., Jnr, E. C. P., Cummings, A. B., & Belin, M. W. (2021). Outcomes of Conductive Keratoplasty Combined with Corneal Crosslinking in Advanced Ectatic Corneal Disease. Clinical Ophthalmology (Auckland, NZ), 15, 1317.
dc.identifier.issn1177-5467
dc.identifier.doi10.2147/OPTH.S259012
dc.identifier.urihttp://hdl.handle.net/10150/660497
dc.description.abstractPurpose: To assess the effectiveness of a novel treatment for patients with advanced corneal ectasia and loss of visual acuity (VA). Conductive keratoplasty (CK) is performed to improve VA followed by epithelium-on (epi-on) corneal crosslinking (CXL) to stabilize the cornea after CK. Methods: Retrospective, exploratory cohort study. Patients with keratoconus or postsurgical ectasia and best spectacle-corrected distance VA (CDVA) ≤ 20/40 were included. Conductive keratoplasty was performed (ViewPoint CK System, Refractec, Inc., Bloomington, MN); followed a day later by epi-on CXL (CXLUSA/CXLO, Bethesda, MD/CXLO Encinitas, CA). Measures included uncorrected distance visual acuity (UDVA) and CDVA, as well as refractive and tomographic measures and tomographic indices. Results: Data from 50 eyes of 45 patients were analyzed. Mean follow-up was 15.1 ± 12.2 months (range: 2 to 51). Overall, UDVA and CDVA improved postoperatively. Subjective refraction and tomographic metrics did not show consistent changes, but changes in tomographic indices were associated with treatment follow-up time. At the 1-year visit, mean UDVA significantly improved over baseline (P = 0.009) by approximately 3 lines; mean CDVA improved significantly (P = 10−5) by approximately 2 lines. No eye lost lines of CDVA. Change in the Index of Surface Variance (ISV) was associated with treatment, and the D-Index trended over follow-up time. Conclusion: Conductive keratoplasty with a proprietary epi-on CXL treatment improved vision in patients with advanced ectasia This CK/epi-on CXL treatment offers the possibility of improved VA for patients with compromised vision due to ectasia. © 2021 Sinjab et al.
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.rightsCopyright © 2021 Sinjab et al.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectCK
dc.subjectConductive keratoplasty
dc.subjectCorneal crosslinking
dc.subjectCrosslinking
dc.subjectEctasia
dc.subjectKeratoconus
dc.subjectThermokeratoplasty
dc.titleOutcomes of conductive keratoplasty combined with corneal crosslinking in advanced ectatic corneal disease
dc.typeArticle
dc.typetext
dc.contributor.departmentDepartment of Ophthalmology, University of Arizona
dc.identifier.journalClinical Ophthalmology
dc.description.noteImmediate access
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleClinical Ophthalmology
refterms.dateFOA2021-07-16T01:28:08Z


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