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dc.contributor.authorVelazquez, F.N.
dc.contributor.authorZhang, L.
dc.contributor.authorViscardi, V.
dc.contributor.authorTrocchia, C.
dc.contributor.authorHannun, Y.A.
dc.contributor.authorObeid, L.M.
dc.contributor.authorSnider, A.J.
dc.date.accessioned2021-07-17T01:39:02Z
dc.date.available2021-07-17T01:39:02Z
dc.date.issued2021
dc.identifier.citationVelazquez, F. N., Zhang, L., Viscardi, V., Trocchia, C., Hannun, Y. A., Obeid, L. M., & Snider, A. J. (2021). Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer. PLoS ONE, 16(5 May).
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0252311
dc.identifier.urihttp://hdl.handle.net/10150/660672
dc.description.abstractBreast cancer is a very heterogeneous disease, and ~30% of breast cancer patients succumb to metastasis, highlighting the need to understand the mechanisms of breast cancer progression in order to identify new molecular targets for treatment. Sphingosine kinase 1 (SK1) has been shown to be upregulated in patients with breast cancer, and several studies have suggested its involvement in breast cancer progression and/or metastasis, mostly based on cell studies. In this work we evaluated the role of SK1 in breast cancer development and metastasis using a transgenic breast cancer model, mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT), that closely resembles the characteristics and evolution of human breast cancer. The results show that SK1 deficiency does not alter tumor latency or growth, but significantly increases the number of metastatic lung nodules and the average metastasis size in the lung of MMTV-PyMT mice. Additionally, analysis of Kaplan-Meier plotter of human disease shows that high SK1 mRNA expression can be associated with a better prognosis for breast cancer patients. These results suggest a metastasis-suppressing function for SK1 in the MMTV-PyMT model of breast cancer, and that its role in regulating human breast cancer progression and metastasis may be dependent on the breast cancer type. Copyright: © 2021 Velazquez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.language.isoen
dc.publisherPublic Library of Science
dc.rightsCopyright © 2021 Velazquez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleLoss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer
dc.typeArticle
dc.typetext
dc.contributor.departmentDepartment of Nutritional Sciences, College of Agriculture and Life Sciences, University of Arizona
dc.identifier.journalPLoS ONE
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitlePLoS ONE
refterms.dateFOA2021-07-17T01:39:02Z


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Copyright © 2021 Velazquez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
Except where otherwise noted, this item's license is described as Copyright © 2021 Velazquez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.