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dc.contributor.advisorBailey, E. Fiona
dc.contributor.authorDeLucia, Claire M.
dc.creatorDeLucia, Claire M.
dc.date.accessioned2021-07-19T20:23:05Z
dc.date.available2021-07-19T20:23:05Z
dc.date.issued2021
dc.identifier.citationDeLucia, Claire M. (2021). Inspiratory Muscle Strength Training: Acute Effects, Dynamic Improvements and Clinical Significance (Doctoral dissertation, University of Arizona, Tucson, USA).
dc.identifier.urihttp://hdl.handle.net/10150/660762
dc.description.abstractInspiratory muscle strength training (IMST) is a form of resistive breathing training traditionally used to strengthen respiratory muscles. In our hands, we have reported significant reductions in blood pressure following six weeks of daily IMST that are driven in part by reductions in systemic vascular resistance. The work set forth in this dissertation addresses outstanding questions resulting from our previous work. Study 1 characterizes the acute cardiovascular and sympathetic response(s) to a single bout of IMST in healthy young adults. We show that IMST acutely increases heart rate with concomitant reductions in sympathetic nervous system outflow. Study 2 assesses the potential for six weeks IMST to alter the cardiovascular response to respiratory muscle fatigue in college-aged adults. The results of this study suggest IMST improves respiratory muscle endurance and as a result, blunts the blood pressure and heart rate responses to respiratory muscle fatigue. Finally, Study 3 documents the effects of six weeks IMST on overnight blood pressure and mediators of systemic vascular resistance in older adults diagnosed with obstructive sleep apnea. In a population that exhibits elevated blood pressure and sympathetic nervous system activity, we show that IMST significantly lowers daytime blood pressure, nighttime systolic blood pressure and resting sympathetic nervous system activity. These studies are the first to characterize the acute cardiovascular effects of IMST and to explore the effects of IMST on mediators of systemic vascular resistance in both healthy and patient populations.
dc.language.isoen
dc.publisherThe University of Arizona.
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBlood pressure
dc.subjectExercise
dc.subjectRespiratory training
dc.subjectSympathetic Activation
dc.titleInspiratory Muscle Strength Training: Acute Effects, Dynamic Improvements and Clinical Significance
dc.typetext
dc.typeElectronic Dissertation
thesis.degree.grantorUniversity of Arizona
thesis.degree.leveldoctoral
dc.contributor.committeememberColetta, Dawn K.
dc.contributor.committeememberFregosi, Ralph F.
dc.contributor.committeememberFuglevand, Andrew J.
dc.contributor.committeememberSeals, Douglas R.
dc.description.releaseRelease after 01/01/2022
thesis.degree.disciplineGraduate College
thesis.degree.disciplinePhysiological Sciences
thesis.degree.namePh.D.


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