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dc.contributor.authorMosconi, L.
dc.contributor.authorBerti, V.
dc.contributor.authorDyke, J.
dc.contributor.authorSchelbaum, E.
dc.contributor.authorJett, S.
dc.contributor.authorLoughlin, L.
dc.contributor.authorJang, G.
dc.contributor.authorRahman, A.
dc.contributor.authorHristov, H.
dc.contributor.authorPahlajani, S.
dc.contributor.authorAndrews, R.
dc.contributor.authorMatthews, D.
dc.contributor.authorEtingin, O.
dc.contributor.authorGanzer, C.
dc.contributor.authorde Leon, M.
dc.contributor.authorIsaacson, R.
dc.contributor.authorBrinton, R.D.
dc.date.accessioned2021-07-22T00:47:31Z
dc.date.available2021-07-22T00:47:31Z
dc.date.issued2021
dc.identifier.citationMosconi, L., Berti, V., Dyke, J., Schelbaum, E., Jett, S., Loughlin, L., Jang, G., Rahman, A., Hristov, H., Pahlajani, S., Andrews, R., Matthews, D., Etingin, O., Ganzer, C., de Leon, M., Isaacson, R., & Brinton, R. D. (2021). Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition. Scientific Reports, 11(1).
dc.identifier.issn2045-2322
dc.identifier.pmid34108509
dc.identifier.doi10.1038/s41598-021-90084-y
dc.identifier.urihttp://hdl.handle.net/10150/660962
dc.description.abstractAll women undergo the menopause transition (MT), a neuro-endocrinological process that impacts aging trajectories of multiple organ systems including brain. The MT occurs over time and is characterized by clinically defined stages with specific neurological symptoms. Yet, little is known of how this process impacts the human brain. This multi-modality neuroimaging study indicates substantial differences in brain structure, connectivity, and energy metabolism across MT stages (pre-menopause, peri-menopause, and post-menopause). These effects involved brain regions subserving higher-order cognitive processes and were specific to menopausal endocrine aging rather than chronological aging, as determined by comparison to age-matched males. Brain biomarkers largely stabilized post-menopause, and gray matter volume (GMV) recovered in key brain regions for cognitive aging. Notably, GMV recovery and in vivo brain mitochondria ATP production correlated with preservation of cognitive performance post-menopause, suggesting adaptive compensatory processes. In parallel to the adaptive process, amyloid-β deposition was more pronounced in peri-menopausal and post-menopausal women carrying apolipoprotein E-4 (APOE-4) genotype, the major genetic risk factor for late-onset Alzheimer’s disease, relative to genotype-matched males. These data show that human menopause is a dynamic neurological transition that significantly impacts brain structure, connectivity, and metabolic profile during midlife endocrine aging of the female brain. © 2021, The Author(s).
dc.language.isoen
dc.publisherNature Research
dc.rightsCopyright © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMenopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition
dc.typeArticle
dc.typetext
dc.contributor.departmentDepartments of Pharmacology and Neurology, College of Medicine, University of Arizona
dc.identifier.journalScientific Reports
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleScientific Reports
refterms.dateFOA2021-07-22T00:47:31Z


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Copyright © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as Copyright © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License.