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dc.contributor.authorZein, Joe G
dc.contributor.authorMcManus, Jeffrey M
dc.contributor.authorSharifi, Nima
dc.contributor.authorErzurum, Serpil C
dc.contributor.authorMarozkina, Nadzeya
dc.contributor.authorLahm, Timothy
dc.contributor.authorGiddings, Olivia
dc.contributor.authorDavis, Michael D
dc.contributor.authorDeBoer, Mark D
dc.contributor.authorComhair, Suzy A
dc.contributor.authorBazeley, Peter
dc.contributor.authorKim, Hyun Jo
dc.contributor.authorBusse, William
dc.contributor.authorCalhoun, William
dc.contributor.authorCastro, Mario
dc.contributor.authorChung, Kian Fan
dc.contributor.authorFahy, John V
dc.contributor.authorIsrael, Elliot
dc.contributor.authorJarjour, Nizar N
dc.contributor.authorLevy, Bruce D
dc.contributor.authorMauger, David T
dc.contributor.authorMoore, Wendy C
dc.contributor.authorOrtega, Victor E
dc.contributor.authorPeters, Michael
dc.contributor.authorBleecker, Eugene R
dc.contributor.authorMeyers, Deborah A
dc.contributor.authorZhao, Yi
dc.contributor.authorWenzel, Sally E
dc.contributor.authorGaston, Benjamin
dc.date.accessioned2021-09-09T19:42:30Z
dc.date.available2021-09-09T19:42:30Z
dc.date.issued2021
dc.identifier.citationZein, J. G., McManus, J. M., Sharifi, N., Erzurum, S. C., Marozkina, N., Lahm, T., Giddings, O., Davis, M. D., DeBoer, M. D., Comhair, S. A., Bazeley, P., Jo Kim, H., Busse, W., Calhoun, W., Castro, M., Chung, K. F., Fahy, J. V., Israel, E., Jarjour, N. N., … Gaston, B. (2021). Benefits of airway androgen receptor expression in human asthma. American Journal of Respiratory and Critical Care Medicine, 204(3), 285–293.en_US
dc.identifier.pmid33779531
dc.identifier.doi10.1164/rccm.202009-3720OC
dc.identifier.urihttp://hdl.handle.net/10150/661430
dc.description.abstractRationale: Androgens are potentially beneficial in asthma, but AR (androgen receptor) has not been studied in human airways.Objectives: To measure whether AR and its ligands are associated with human asthma outcomes.Methods: We compared the effects of AR expression on lung function, symptom scores, and fractional exhaled nitric oxide (FeNO) in adults enrolled in SARP (Severe Asthma Research Program). The impact of sex and of androgens on asthma outcomes was also evaluated in the SARP with validation studies in the Cleveland Clinic Health System and the NHANES (U.S. National Health and Nutrition Examination Survey).Measurements and Main Results: In SARP (n = 128), AR gene expression from bronchoscopic epithelial brushings was positively associated with both FEV1/FVC ratio (R2 = 0.135, P = 0.0002) and the total Asthma Quality of Life Questionnaire score (R2 = 0.056, P = 0.016) and was negatively associated with FeNO (R2 = 0.178, P = 9.8 × 10-6) and NOS2 (nitric oxide synthase gene) expression (R2 = 0.281, P = 1.2 × 10-10). In SARP (n = 1,659), the Cleveland Clinic Health System (n = 32,527), and the NHANES (n = 2,629), women had more asthma exacerbations and emergency department visits than men. The levels of the AR ligand precursor dehydroepiandrosterone sulfate correlated positively with the FEV1 in both women and men.Conclusions: Higher bronchial AR expression and higher androgen levels are associated with better lung function, fewer symptoms, and a lower FeNO in human asthma. The role of androgens should be considered in asthma management.en_US
dc.language.isoenen_US
dc.publisherAmerican Thoracic Societyen_US
dc.rightsCopyright © 2021 by the American Thoracic Society.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.subjectairflow obstructionen_US
dc.subjectairway inflammationen_US
dc.subjectandrogensen_US
dc.subjectasthmaen_US
dc.titleBenefits of Airway Androgen Receptor Expression in Human Asthmaen_US
dc.typeArticleen_US
dc.identifier.eissn1535-4970
dc.contributor.departmentDivision of Genetics, Genomics, and Precision Medicine, Department of Medicine, University of Arizonaen_US
dc.identifier.journalAmerican Journal of Respiratory and Critical Care Medicineen_US
dc.description.note12 month embargo; published 01 August 2021en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleAmerican journal of respiratory and critical care medicine
dc.source.volume204
dc.source.issue3
dc.source.beginpage285
dc.source.endpage293
dc.source.countryUnited States
dc.source.countryUnited States


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