Cardiorespiratory effects of three infusion doses of adenosine in conscious goats: A preliminary study
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College of Veterinary Medicine, University of ArizonaIssue Date
2021
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MDPI AGCitation
Salah, E., Abouelfetouh, M. M., Englar, R. E., Ding, M., & Ding, Y. (2021). Cardiorespiratory effects of three infusion doses of adenosine in conscious goats: A preliminary study. Veterinary Sciences, 8(8).Journal
Veterinary SciencesRights
Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Adenosine (AD) has been implicated in human healthcare as an endogenous signaling nu-cleotide in both physiologic and pathologic states. The effects of AD on cardiorespiratory parameters in ruminants has not yet been studied. The objective of this study was to evaluate the cardiac and respiratory changes that resulted from an intravenous AD infusion in goats. Six clinically healthy adult goats weighing 28 ± 2 kg were randomly assigned to one of four treatments in a crossover design with a seven day washout period. The goats received a 0.9 % saline solution (SAL treatment) and three AD treatments (AD 50, 100 and 200) intravenously at a dose rate of 50, 100 and 200 µg/kg/min. Cardiorespiratory and key cardiac parameters were measured before the treatment (baseline), during the infusion (dInf) and at 1, 3, 5 and 10 min after each infusion was discontinued. The AD 100 produced a significant increase in HR (p = 0.001) and the AD 200 resulted in significant rises in HR (p = 0.006) and RR (p = 0.001) compared with the baseline. This study concluded that the AD infusion could trigger an increase in HR and RR in a dose-dependent manner in healthy goats. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Note
Open access journalISSN
2306-7381Version
Final published versionae974a485f413a2113503eed53cd6c53
10.3390/vetsci8080158
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Except where otherwise noted, this item's license is described as Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).