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dc.contributor.authorBland, V. L.
dc.contributor.authorKlimentidis, Y. C.
dc.contributor.authorBea, J. W.
dc.contributor.authorRoe, D. J.
dc.contributor.authorFunk, J. L.
dc.contributor.authorGoing, S. B.
dc.date.accessioned2021-09-21T23:43:55Z
dc.date.available2021-09-21T23:43:55Z
dc.date.issued2021-09-06
dc.identifier.citationBland, V. L., Klimentidis, Y. C., Bea, J. W., Roe, D. J., Funk, J. L., & Going, S. B. (2021). Cross-sectional associations between adipose tissue depots and areal bone mineral density in the UK Biobank imaging study. Osteoporosis International.en_US
dc.identifier.issn0937-941X
dc.identifier.doi10.1007/s00198-021-06140-w
dc.identifier.urihttp://hdl.handle.net/10150/661850
dc.description.abstractSummary: The relationship between obesity and osteoporosis is poorly understood. In this study, we assessed the association between adiposity and bone. The fat–bone relationship was dependent on sex, body mass index classification, and menopausal status. Results highlight the importance of accounting for direct measures of adiposity (beyond BMI) and menopause status. Introduction: Assess the relationship between direct measures of adiposity (total body fat mass, visceral adipose tissue, and abdominal subcutaneous adipose tissue) with the whole body and clinically relevant bone sites of the lumbar spine, and femoral neck areal bone mineral density (aBMD) in men and women. Methods: This cross-sectional analysis was conducted utilizing de-identified data from the UK Biobank on participants (n = 3674) with available dual-energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI) data. Sex-stratified multiple linear regression was used to assess the relationship between adiposity measures and aBMD outcomes, controlling for age, race, total body lean mass (DXA), height, BMI class, physical activity, smoking, menopausal status (women), and hormone use (women). Results: In men, significant interactions were observed between measures of adiposity and BMI on aBMD for the whole body and lumbar spine. Interactions indicated a positive relationship between adiposity and aBMD in men classified as normal weight, but an inverse relationship in men with elevated BMI. In women, significant interactions between adiposity measures and menopausal status were observed primarily for the whole body and femoral neck aBMD bone outcomes which indicated a negative relationship between adiposity and aBMD in premenopausal women, but a positive relationship in postmenopausal women. Conclusion: Total body adiposity, abdominal subcutaneous adipose tissue, and visceral adipose tissue were all significantly associated with aBMD in both men and women. The strength and direction of association were dependent on sex, BMI classification, and menopausal status (women).en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.rights© International Osteoporosis Foundation and National Osteoporosis Foundation 2021.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.subjectAdiposityen_US
dc.subjectAgingen_US
dc.subjectBoneen_US
dc.subjectDXAen_US
dc.subjectMenopauseen_US
dc.subjectVisceral faten_US
dc.titleCross-sectional associations between adipose tissue depots and areal bone mineral density in the UK Biobank imaging studyen_US
dc.typeArticleen_US
dc.identifier.eissn1433-2965
dc.contributor.departmentDepartment of Epidemiology and Biostatistics, University of Arizonaen_US
dc.contributor.departmentDepartment of Health Promotion Sciences, University of Arizonaen_US
dc.contributor.departmentUniversity of Arizona Cancer Centeren_US
dc.contributor.departmentDepartment of Nutritional Sciences, University of Arizonaen_US
dc.contributor.departmentDepartment of Medicine, University of Arizonaen_US
dc.identifier.journalOsteoporosis Internationalen_US
dc.description.note12 month embargo; published: 06 September 2021en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.identifier.pii6140
dc.source.journaltitleOsteoporosis International


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