Budget impact analysis of comprehensive genomic profiling in patients with advanced non-small-cell lung cancer
Publisher
American Society of Clinical OncologyCitation
Harvey, M. J., Cunningham, R., Sawchyn, B., Montesion, M., Reddy, P., McBride, A., & Chawla, A. J. (2021). Budget impact analysis of comprehensive genomic profiling in patients with advanced non-small-cell lung cancer. JCO Precision Oncology.Journal
JCO Precision OncologyRights
Copyright © 2021 American Society of Clinical Oncology. All rights reserved.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
PURPOSE This study assessed the economic impact of increased use of comprehensive genomic profiling (CGP) versus conventional testing strategies among patients with advanced non-small-cell lung cancer (aNSCLC) from a US commercial health plan perspective. METHODS A decision analytic model was developed to estimate the incremental benefits and costs across testing methodologies (CGP v non-CGP), as well as across sample types (tissue-based and liquid-based), for patients with newly diagnosed aNSCLC. Model outcomes included total direct costs, testing costs, and per member per month budget impact. Secondary model outcomes included the number of patients needed to test with CGP to add 1 life-year, and the number of patients needed to test with CGP to treat one individual with a biomarkermatched therapy. RESULTS In a hypothetical 2,000,000-member health plan, 790 members were estimated to have incident aNSCLC; 609 underwent molecular diagnostic testing with 122 (20%) tested with CGP (109 tissue-based and 13 liquid) in the base-case. An increase in CGP from 20% to 30% (an additional 61 patients tested with CGP) was associated with 3.11 additional life-years gained and a $0.01 in US dollars per member per month budget impact. Approximately 19.6 patients would need to be tested with CGP versus non-CGP to add one life-year and 5.9 patients would need to be tested with CGP to treat at least one patient with a biomarker-matched therapy. CONCLUSION An increase in CGP from 20% to 30% among patients with aNSCLC undergoing molecular diagnostic testing was associated with modest budget impact, most of which was attributable to prolonged survival associated with increased use of more effective treatments. © 2021 American Society of Clinical Oncology. All rights reserved.Note
12 month embargo; first published: 14 October 2021ISSN
2473-4284Version
Final published versionae974a485f413a2113503eed53cd6c53
10.1200/PO.20.00540